Senior Research Associate-Protein Assay Development – Spatial Biology

10x Genomics•Pleasanton, CA

About The Position

10x Genomics is seeking a Senior Research Associate to join its Spatial Team and contribute to a collaborative R&D effort developing technologies that map proteins and other biomolecules directly within intact tissue. The role supports the end-to-end assay process, including antibody clone screening, protocol optimization, library preparation, instrument operation, and initial data analysis, with a focus on achieving high-quality results. The successful candidate will work closely with scientists specializing in spatial analysis and contribute to the development of tools in spatial biology. The role calls for a strong biological sciences background, hands-on experience conducting spatial assays to probe proteins and RNA in tissues, clear communication, attention to detail, and effective collaboration with interdisciplinary teams. The candidate should be motivated, proactive, adaptable, and able to manage multiple priorities in a fast-paced environment. This is a full-time position. Compensation includes base pay, equity grant eligibility, health and retirement benefits, and eligibility for an annual bonus or sales incentive program. The actual base pay depends on the candidate's skills, qualifications, and experience; no salary range is specified.

Requirements

Bachelor's or master's degree in Cell Biology, Immunology, Biomedical Sciences, Molecular Biology, or a related scientific field.
For candidates with a bachelor's degree, at least 5 years of hands-on experience in an industry setting; for candidates with a master's degree, at least 3 years of hands-on experience in an industry setting.
Experience with tissue processing, histology, immunohistochemistry, immunostaining, multiplex protein assays, and/or in situ hybridization techniques.
Experience working with antibodies and familiarity with monoclonal antibody quality control, conjugation, and/or functional testing.
A proven track record of using, optimizing, and troubleshooting protocols in tissues.

Nice To Haves

Tissue handling experience, including fresh frozen tissue, FFPE, and antigen retrieval.
Strong organizational skills and the ability to plan and structure work.
Excellent interpersonal skills, including written and oral communication.
Ability to work in a fast-paced and quickly changing environment.
Basic coding skills.
Experience with image analysis software such as CellProfiler or FIJI.
Light and fluorescence microscopy experience, including confocal or standard epifluorescence microscopy.
Work experience in similar positions in academia, industry, or a service provider or core facility.

Responsibilities

Perform protein assays on tissue sections mounted on microscope glass slides.
Conduct antibody clone screening using high-throughput fluorescent microscopy imaging of processed tissue samples, and preprocess image data.
Perform in situ library preparation workflows.
Help troubleshoot assays and optimize protocols for specific tissue samples.
Deliver processed image data to computational biologists and collaborate with them on image data analysis.
Maintain relevant project documentation and records.