Senior Research Associate-Protein Assay Development – Spatial Biology

10x Genomics•Pleasanton, CA

About The Position

10x Genomics is seeking a Senior Research Associate to join its Spatial Team and contribute to a collaborative R&D effort developing technologies that map proteins and other biomolecules directly within intact tissue. The role supports the full assay process, including antibody clone screening, protocol optimization, library preparation, instrument operation, and initial data analysis, with a focus on achieving high-quality results. The successful candidate will work closely with scientists in spatial analysis and participate in developing tools in spatial biology. The position is suited to a detail-oriented, proactive, adaptable scientist with a strong biological sciences background and significant experience conducting spatial assays to probe proteins and RNA in tissues. The candidate will collaborate with interdisciplinary teams, incorporate feedback into experimental design, manage changing priorities, and deliver results in a fast-paced environment. This is a full-time position. Compensation includes base pay, equity grants, health and retirement benefits, and eligibility for an annual bonus or sales incentive program. The base pay range is not provided in the posting.

Requirements

B.S. or M.S. in Cell Biology, Immunology, Biomedical Sciences, Molecular Biology, or a related scientific field.
For candidates with a B.S., at least 5 years of hands-on experience in an industry setting; for candidates with an M.S., at least 3 years of hands-on experience in an industry setting.
Experience with tissue processing, histology, immunohistochemistry, immunostaining, multiplex protein assays, and/or in situ hybridization techniques.
Experience working with antibodies and familiarity with monoclonal antibody quality control, conjugation, and/or functional testing.
A proven track record of using, optimizing, and troubleshooting protocols in tissues.

Nice To Haves

Tissue handling experience, including fresh frozen tissue, FFPE, or antigen retrieval.
Strong organizational skills and ability to plan and structure work.
Excellent written and oral communication and interpersonal skills.
Ability to work in a fast-paced and rapidly changing environment.
Basic coding skills.
Image analysis experience with relevant software such as CellProfiler or FIJI.
Light and fluorescence microscopy experience, including confocal or standard epifluorescence microscopy.
Work experience in similar positions in academia, industry, or a service provider/core facility.

Responsibilities

Perform protein assays on tissue sections mounted on microscope glass slides.
Screen antibody clones using high-throughput fluorescent microscopy imaging of processed tissue samples, and preprocess image data.
Perform in situ library preparation workflows.
Participate in assay troubleshooting and protocol optimization for specific tissue samples.
Deliver processed image data to computational biologists and work closely with them on image data analysis.
Maintain project-related documentation and records.