Research Technologist I - Ma Lab

Versiti, Inc.•Wauwatosa, WI

About The Position

Versiti is a fusion of donors, scientific curiosity, and precision medicine that recognize the gifts of blood and life are precious. We are home to the world-renowned Blood Research Institute, we enable life saving gifts from our donors, and provide the science behind the medicine through our diagnostic laboratories. Versiti brings together outstanding minds with unparalleled experience in transfusion medicine, transplantation, stem cells and cellular therapies, oncology and genomics, diagnostic lab services, and medical and scientific expertise. This combination of skill and knowledge results in improved patient outcomes, higher quality services and reduced cost of care for hospitals, blood centers, hospital systems, research and educational institutions, and other health care providers. At Versiti, we are passionate about improving the lives of patients and helping our healthcare partners thrive. Position Summary Performs laboratory assays and complex experiments to elucidate novel research questions. The Ma Lab studies integrin signaling in blood cells. Integrin family receptors deliver bidirectional signaling (inside-out and outside-in) across the cell plasma membrane, modulating cell adhesion, migration, proliferation, differentiation, and other functions. Integrin signaling involves a series of molecular events within cells that enable integrins to bridge the crosstalk between the extracellular milieu and cytoskeletal changes, as well as cytoplasmic signaling cascades. Integrin activation is tightly regulated by integrin cytoplasmic tail binding proteins (ICBPs). The interaction between integrins and ICBPs defines the activation states and functional activities of integrins. Dysfunction of integrin signaling often leads to integrin-associated pathological conditions, including inflammatory defects and bleeding disorders. The long-term goal of our research is to elucidate the detailed molecular mechanisms regulating integrin signaling and to explore novel and safer therapeutic strategies for preventing and treating integrin-associated diseases, such as inflammation and thrombosis. The ongoing research in our laboratory focuses on Kindlin-3, an essential integrin signaling adaptor molecule and one of the key ICBPs expressed in cells of hematopoietic origin. Kindlin-3 plays a critical role in supporting integrin signaling in blood cells. Kindlin-3 deficiency causes type-III leukocyte adhesion deficiency (LAD-III) in humans, characterized by severe bleeding disorders and recurrent infections. Specifically, we are investigating the novel role of Kindlin-3 in platelets and myeloid cells in modulating immunothrombosis under various pathological conditions, including deep vein thrombosis and endotoxemia. Our experimental approaches range from biochemical and cellular analyses to small animal models. Our study may facilitate the development of more specific and safer strategies for treating immunothrombotic complications across a wide range of diseases. Total Rewards Package BenefitsVersiti provides a comprehensive benefits package based on your job classification. Full-time regular employes are eligible for Medical, Dental, and Vision Plans, Paid Time Off (PTO) and Holidays, Short- and Long-term disability, life insurance, 7% match dollar for dollar 401(k), voluntary programs, discount programs, others.

Requirements

Bachelor's Degree from an accredited college or university in biology, chemistry or equivalent scientific discipline required
1-3 years relevant laboratory experience required
Knowledge of theoretical basis of work being performed preferred
Ability to work independently with minimum supervision required
Proficient in research laboratory techniques required
Strong detail orientation and analytical ability required
Ability to accurately carry out experiments and tasks by following established guidelines required
Ability to prioritize and execute multiple tasks required
Effective organizational and communication skills required
Personal computer required
Specialized research equipment preferred

Responsibilities

Works with Principal Investigator to plan, structure, and execute research experiments.
Troubleshoots assays and customizes experimental tools
Coordinates external and internal resources necessary for completion of research plan
Generates clear and complete records of experimental work
Participates in publication of research results
Performs other duties as required or assigned to technically support scientific projects in the lab and other tasks that are assigned by Principal Investigator
Performs other duties as required or assigned which are reasonably within the scope of the duties in this job classification
Understands and performs in accordance with all applicable regulatory and compliance requirements
Complies with all standard operating policies and procedures