Research Lab Technician I

Mass General Brigham•Boston, MA

5d•$29•Onsite

About The Position

Under general supervision of the Principal Investigator, this role provides technical support for the Specialized Histopathology Core Laboratory. The position involves performing tests using histologic, molecular cytogenetic, immunohistochemical, and in situ methods, and analyzing data using basic statistics. The laboratory focuses on the pathology of neurodegenerative disease. This full-time research assistant position in the Department of Pathology at Brigham and Women’s Hospital will conduct research utilizing ultrasensitive seed amplification assays (SAA) alongside ultrasensitive single molecule array (Simoa) and Molecular On-bead Signal Amplification for Individual Counting (MOSAIC) assays. Specific applications include the protein aggregation of recombinantly expressed disordered proteins seeded with patient cerebral-spinal fluid or other bio-fluids, using existing SAA and Simoa/MOSAIC technology or developing new diagnostic techniques. The candidate will work independently to perform experiments and measure biomarkers undetectable by conventional methods, contributing to new insights into diagnostics and treatments for neurodegenerative diseases.

Requirements

Bachelor's Degree in Biological/physical science required.
Sound analytical and organizational skills
High degree of computer literacy.
Good oral and written communication skills
Must be able to logically and effectively structure tasks and set priorities.
Ability to identify potential problems and trouble-shoot solutions.
Demonstrated ability to analyze data statistically and to logically present it.

Nice To Haves

Some prior research preferred but not essential.

Responsibilities

Independently performs routine and non-routine experiments which are moderate to complex, including preparing reagents, evaluating binding reagent viability, expressing and purifying protein from E. Coli, visualizing protein aggregates using fluorescence microscopy, and generating and developing microfluidic and droplet microfluidic encapsulation techniques.
Calculates, transcribes, and analyzes data using moderate to advanced statistical techniques.
Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication.
Corresponds and communicates progress professionally with collaborators and the scientific community.
In collaboration with the PI or Research Manager, establishes new and modifies existing research techniques.
Coordinates schedule of tests and procedures.
Documents experimental work accurately and in detail.
Coordinates lab activities such as bio-safety trainings.
Assists in the orientation and training of new staff.
Ordering and inventory of laboratory supplies.
All other duties as assigned.