Research Lab Technician I

Mass General Brigham•Boston, MA

13h•Onsite

About The Position

Under general supervision of the Principal Investigator, this role provides technical support for the Specialized Histopathology Core Laboratory at Brigham and Women's Hospital. The position involves performing tests using histologic, molecular cytogenetic, immunohistochemical, and in situ methods, and analyzing data using basic statistics. The laboratory focuses on the pathology of neurodegenerative disease. This full-time research assistant position will utilize ultrasensitive seed amplification assays (SAA) alongside ultrasensitive single molecule array (Simoa) and Molecular On-bead Signal Amplification for Individual Counting (MOSAIC) assays. Specific applications include studying protein aggregation in patient bio-fluids and developing new diagnostic techniques. The candidate will work independently to perform experiments and measure biomarkers that are undetectable by conventional methods, contributing to new insights into diagnostics and treatments for neurodegenerative diseases.

Requirements

Bachelor's Degree in Biological/physical science required.
Sound analytical and organizational skills
High degree of computer literacy.
Good oral and written communication skills
Must be able to logically and effectively structure tasks and set priorities.
Ability to identify potential problems and trouble-shoot solutions.
Demonstrated ability to analyze data statistically and to logically present it.

Nice To Haves

Some prior research preferred but not essential.

Responsibilities

Independently performs routine and non-routine experiments which are moderate to complex.
Experimental work may include preparing reagents and evaluating binding reagent viability in assay platform, expressing and purifying protein from E. Coli, visualizing protein aggregates using fluorescence microscopy, and generating and developing microfluidic and droplet microfluidic encapsuolation techniques.
Calculate, transcribes and analyzes data using moderate to advanced statistical techniques.
Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication.
Corresponds and communicates progress professionally with collaborators and scientific community.
In collaboration with PI or Research Manager, establishes new and modifies existing research techniques.
Coordinates schedule of tests and procedures.
Documents experimental work accurately and in detail.
Coordinates lab activities such as bio-safety trainings.
Assists in the orientation and training of new staff.
Ordering and inventory of laboratory supplies.
All other duties as assigned.