Research Scientist

Jazz Pharmaceuticals • Durham, NC

10d • Onsite

About The Position

Jazz Pharmaceuticals is seeking a Research Scientist for a full-time, laboratory-based position. The scientist will design and execute experiments with little supervision to investigate the efficacy and mechanisms of action of anticancer compounds, with a particular focus on receptor tyrosine kinases (RTKs), preferably HER2. The role includes documenting and archiving protocols, data, analyses, and conclusions according to laboratory procedures, and contributing to research communications such as publications, conference presentations, abstracts, and patent applications. The scientist will work under general supervision across multiple projects.

Responsibilities include managing cancer and normal cell-line cultures; conducting in vitro efficacy, mechanism-of-action, target-validation, and biomarker studies; engineering stable cell lines using CRISPR and inducible expression; and creating or adapting reporter systems for molecular targets. The position also involves presenting results, supporting preparation of abstracts and manuscripts, and developing operational, documentation, and troubleshooting procedures. Other responsibilities and projects may be assigned by the Company.

The role requires demonstrated expertise in RTK biology, preferably HER2, including characterization of signaling, pathway modulation, and therapeutic mechanisms. Candidates must have at least three years of industry or postdoctoral oncology experience and experience with oncology and pharmacology assays and techniques. A Ph.D. in a related scientific field or a master’s degree with relevant experience is required. The position is onsite, as indicated by the job posting’s onsite designation.

Requirements

• Demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2, and experience characterizing RTK signaling, pathway modulation, and therapeutic mechanisms of action.
• Three or more years of industry or postdoctoral experience in oncology.
• Experience with oncology and pharmacology assays and techniques.
• Ph.D. in cancer biology, molecular or cell biology, biochemistry, pharmacology, or a related field, or a master’s degree with relevant experience.
• Exceptional written and verbal communication skills, including publications and conference presentations.
• Ability to work as a team player, stay highly organized, and manage multiple concurrent projects with minimal oversight.
• Ability to anticipate challenges and proactively implement solutions.
• Computer proficiency.
• Experience advancing numerous projects simultaneously.
• Ability to identify and initiate tasks, set completion goals, create timelines, and monitor progress.
• Strong sense of urgency in meeting business needs and a positive, hands-on approach.
• Ability to respond professionally to changing priorities and timelines.
• Demonstrated success working in a matrix, cross-functional environment.
• Ability to communicate clearly in writing and orally, work independently, and maintain strong attention to detail.
• Ability to perform routine laboratory work, sit or stand at a computer for extended periods, and type.
• Ability to occasionally move about the office to access file cabinets and equipment, and occasionally lift objects up to 25 pounds.

Nice To Haves

• Specific experience with HER2, preferred as part of the RTK biology expertise.

Responsibilities

• Manage cell culture of cancer and normal cell lines.
• Perform in vitro efficacy, mechanism-of-action, target-validation, and biomarker studies with cancer therapeutics, emphasizing RTK/HER2-driven models.
• Create stable cell lines using CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
• Create or adapt reporter systems for relevant molecular targets.
• Present summary results for internal communications and external presentations.
• Support preparation of conference abstracts and manuscripts for publication as needed.
• Develop appropriate operational, data documentation, and troubleshooting procedures.
• Document and archive experimental protocols, data, analyses, and conclusions according to established laboratory procedures.
• Contribute to communication of research through publications, conference presentations, abstracts, and patent applications.
• Carry out other responsibilities and projects assigned by the Company.

Benefits

• Medical insurance
• Dental insurance
• Vision insurance
• 401(k) retirement savings plan
• Flexible paid vacation
• Potential eligibility for a discretionary annual cash bonus or incentive compensation, depending on role
• Potential eligibility for discretionary equity grants

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree