Research Scientist - Song Lab
About The Position
The Song Lab at Massachusetts General Hospital and Harvard Medical School investigates the molecular mechanisms underlying neurodegenerative diseases, including Alzheimer’s disease, ALS/FTD, and Huntington’s disease. Our research integrates mechanistic neurobiology, human iPSC-derived neuronal models, advanced imaging, proteomics, and emerging AI-enabled technologies to understand how disease-associated proteins disrupt neuronal function and to translate these discoveries into novel biomarkers and therapeutic strategies. The successful candidate will join a highly collaborative and interdisciplinary research environment spanning basic and translational neuroscience, structural biology, and AI-driven protein design. A major focus of this position will be a collaborative project evaluating AI-assisted de novo protein designs targeting pathological forms of amyloid-β, tau, and TDP-43, with the goal of developing new tools for disease detection and therapeutic intervention. Candidates with expertise in one or more of the following areas are particularly encouraged to apply: protein biochemistry, cellular and animal models of neurodegeneration, human tissue processing and analysis, advanced microscopy, and multi-omics approaches. Experience working across disciplines and an interest in translating mechanistic discoveries into biomarkers and therapeutics are highly valued. In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.
Requirements
- Doctorate Related Field of Study required
- Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required
- Excellent research skills.
- Demonstrated evidence of specific scientific competence in field.
- Demonstrated broad knowledge of field.
- Evidence of potential for scientific creativity and original thought.
- Able to exercise independent judgment and leadership.
- Ability to contribute to publications.
Nice To Haves
- Expertise in protein biochemistry
- Expertise in cellular and animal models of neurodegeneration
- Expertise in human tissue processing and analysis
- Expertise in advanced microscopy
- Expertise in multi-omics approaches
- Experience working across disciplines
- Interest in translating mechanistic discoveries into biomarkers and therapeutics
Responsibilities
- Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
- Contributes to the design and execution of experiments and/or research projects.
- Exercises judgment in selecting methods and technologies to obtain results.
- May collaborate with external researchers and/or receive external project funding support.
- Presents results and prepares publications.
- May assist PI in the training and supervision of other staff.
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What This Job Offers
Job Type
Part-time
Career Level
Senior
Education Level
Ph.D. or professional degree
