Research Scientist

University of Louisville • Aurora, CO

7d

About The Position

The Department of Microbiology and Immunology is seeking a technically skilled Research Scientist to lead a cancer immunotherapy research program focused on improving T-cell homing into solid tumors. The role involves research on T-cell biology, including primary cell culture, expansion, manipulation, phenotyping, and adoptive transfers into mice to analyze specific phenotypes. The scientist will develop and validate methods for viral transduction of T-cells for ectopic expression of homing molecules, including chemokine receptors.

The position requires independent experimental design, data processing, statistical analysis, and interpretation of complex datasets. The scientist will prepare technical reports, manuscripts, grant applications, and presentations, and present findings at laboratory meetings, scientific conferences, and other professional venues. The role also includes training graduate students, postdoctoral researchers, and staff in proper instrument use.

Requirements

• Master's degree in a related field and four years of relevant experience, or an equivalent combination of education and experience.
• Strong background in immunology and expertise in T-cell biology, including primary cell culture, expansion, manipulation, phenotyping, and adoptive transfers into mice.
• Ability to independently design experiments, process data, perform statistical analysis, and interpret complex datasets.
• Excellent communication and scientific writing skills.
• Strong commitment to research excellence and ability to work collaboratively while mentoring students and laboratory personnel.
• Organization, project management, analytical, and critical-thinking skills; strong work ethic and interpersonal skills; ability to work in a team.
• Experience with training and operation of laboratory instruments, developing T-cell phenotype analysis methods, troubleshooting, and handling and training in new technologies.

Nice To Haves

• PhD, MD, DVM, or related doctoral degree with 4–6 years of experience in immunology, T-cell function or regulation, or related biomedical research fields.
• Expertise in culture, manipulation, and in vivo analysis of function.
• Strong publication record and demonstrated success in collaborative research.
• Experience in multiomics and translational biomedical research.

Responsibilities

• Design and implement experimental strategies to enhance T-cell homing to solid tumors.
• Develop methods for viral transduction of murine and human T-cells.
• Maintain and manage genetically altered mice that develop spontaneous tumors, including ApcMin mice in various backgrounds such as leukotriene B4 receptor BLT1-null mice and Rag-KO mice.
• Execute implantable tumor models in diverse mouse backgrounds and analyze tumor phenotypes in mouse models.
• Characterize human T-cells, including cancer-patient-derived cells, through lentiviral transduction and phenotype analysis.
• Design experiments, process data, perform statistical analyses, and interpret complex datasets.
• Prepare technical reports, manuscripts, grant applications, and presentations; present findings at laboratory meetings, scientific conferences, and other professional venues.
• Train graduate students, postdocs, and staff in proper instrument use.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level