Research Scientist, Proteomics

Inotiv•Nashville, TN

1d•Onsite

About The Position

Inotiv is a growing contemporary drug discovery and development company where we “Play to Win” in an industry rich with opportunity. Together, we face challenges and together we win in the delivery of world-class drug discovery and development solutions that impact the health and well-being of people all over the world. There’s an opportunity for everyone at all phases of a career, each individual’s unique skill set has an impact on the work we conduct. If you have the talent and desire to impact the quality of people’s lives, we have the career opportunities to make it happen. Join us in embracing research and science to impact the health and well-being of people all over the world. As a leading contract research organization (CRO), Inotiv supports discovery and nonclinical development through investigational new drug (IND) and beyond. By leveraging our deep expertise and scientific capabilities, we help you increase efficiency, improve data, and reduce the cost of taking new drugs to market. By providing critical research models and related services, we help researchers realize the full potential of their R&D projects, all while working together to build a healthier and safer world. We hope you consider our opportunities and a future with Inotiv!

Requirements

BS, or MS, or equivalent degree in Chemistry, Biochemistry, Biology, Molecular Biology, or related field with qualifying laboratory experience in degree program
A basic understanding of processes related to Bioanalysis including sample preparation, instrument / equipment operation and data processing and reporting.
Experience with analysis of proteins and peptides by mass spectrometry, including protein-specific extraction, separation, and purification methods (e.g., in-solution or on-bead digestion, S-Trap, SP3, and C18/SPE peptide desalting).
Experience with, or aptitude to learn, automated sample-preparation platforms, such as the Thermo KingFisher (magnetic bead–based protein/peptide cleanup and SP3) and the Agilent Bravo / AssayMAP (automated liquid handling and cartridge-based peptide desalting).
Comfort working with plate-based, high-throughput workflows (e.g., 96-well processing) and large sample cohorts.
An attitude for quality, an eye for detail, the ability to follow written instructions and work effectively with management to complete assigned tasks.
Documentation discipline and the ability to follow SOPs and written protocols precisely; familiarity with GLP/GMP/GCP principles is a plus.
Ability to use a computer and an electronic lab notebook (ELN) to record experimental detail, and to compile and maintain databases for records and inventory, utilizing the appropriate software.
A working knowledge and awareness of general laboratory procedures.
Good written and oral communication skills.
Ability to adhere to all safety regulations and procedures.
Ability to read, write, speak and understand English

Nice To Haves

Experience with software for analysis of mass spectrometry data.

Responsibilities

Follow SOPs and other applicable laboratory or company procedures
Maintain confidential information consistent with Inotiv corporate policy
Demonstrate Inotiv Core Values
Interact with clients, other employees, and the community in a professional manner
Support and participate in company initiatives
Perform other duties as assigned
Following the safety rules in the lab and maintaining a safe working environment.
Operating lab equipment and performing analyses according to the Operation Manuals, SOPs, Best Practices, and training.
Performing proteomic sample preparation in support of discovery and translational studies, including: Protein extraction and lysis, reduction and alkylation, and enzymatic (e.g., tryptic) digestion.
Peptide cleanup and desalting (S-Trap, SP3, SPE) and protein/peptide quantification.
Preparing buffers, reagents, and stock solutions, and verifying their composition.
Preparing samples through LC-MS injection and assisting with data acquisition as instructed.
Operating, programming, and maintaining automated liquid-handling and bead-based sample-preparation systems (e.g., KingFisher, Bravo) to support reproducible, plate-based, high-throughput proteomic processing.
Recording results accurately in the ELN and contributing to data summaries and study documentation.
Notifying the Lab Manager and/or Principal Investigator of any deviations from the study protocol/SOPs/Best Practices or unexpected processes preventing the proper completion of sample processing and documenting as required.
Observing deadlines, producing timely results or communicating to management when deadlines cannot be accomplished.
Performing assigned general lab tasks, including data logging, routine maintenance of equipment, and general housekeeping.
Ordering reagents, parts and/or materials needed for the functioning of the Lab.
Handling, inventorying and managing incoming materials and samples, waste and shipping of samples to outside parties when needed.
Ensuring training files are properly maintained by keeping his/her CV current and for providing copies of certificates or documentation of training.
Demonstrating an understanding of Best Practices and SOPs, and applying Good Laboratory Practice principles (21 CFR Part 58) where studies are conducted under regulatory requirements.