Research Associate II, High-Throughput Screening

Camp 4 Ranch•Cambridge, MA

2d•$85,000 - $110,000•Onsite

About The Position

CAMP4 Therapeutics is seeking a motivated Research Associate II to join its high-throughput screening team. The role supports the discovery, characterization, and optimization of antisense oligonucleotide (ASO) therapeutics using CAMP4’s proprietary RAP platform. The successful candidate will execute, optimize, and automate in vitro screening workflows; culture relevant cell models; generate molecular data; and collaborate with Discovery, Chemistry, and Data Science colleagues. The position is based in Watertown, Massachusetts, and reports to the Director, Platform. The role is suited to a hands-on scientist with careful experimental execution, strong organization, curiosity, creativity, and teamwork. Responsibilities include high-throughput screening, laboratory automation, mammalian cell culture, molecular assays, data analysis and communication, assay and workflow development, recordkeeping, and routine laboratory operations. CAMP4 develops treatments for genetic diseases by targeting regulatory RNAs with therapeutic ASOs to amplify mRNA and increase healthy protein production. The anticipated salary range is $85,000–$110,000. Employees are eligible for an annual bonus and equity incentive opportunities.

Requirements

BS or MS degree in molecular biology, biochemistry, cell biology, bioengineering, or a related discipline.
Relevant research experience in an industry or academic setting: 3 or more years with a BS degree, or 1 or more years with an MS degree.
Extensive hands-on experience with mammalian cell culture and cell-based assays.
Experience with basic molecular biology techniques, including RNA isolation, quantitative PCR, and western blotting.
Ability to execute experiments carefully, document work thoroughly, and deliver reproducible results.
Working proficiency with Microsoft Office, GraphPad, R, or similar software.
Flexibility and comfort managing multiple responsibilities and executing on multiple projects in parallel.
Attention to detail, high professional integrity, commitment to excellence in execution, and ability to manage tasks and projects independently.
Clear written and verbal communication skills and ability to present data to multidisciplinary audiences.
Collaborative, creative, adaptable, and self-motivated, with a commitment to scientific rigor and high-quality execution.

Nice To Haves

Biotechnology or pharmaceutical industry experience.
Experience with liquid-handling automation and high-throughput screening.
Experience with primary cells, differentiated iPSC-derived cells, dPCR, ASOs, or other oligonucleotide therapeutics.
Experience with functional genomics or CRISPR-based screening.

Responsibilities

Plan and execute high-throughput in vitro screens supporting Platform and Discovery efforts to identify ASO candidates that modulate expression of disease-relevant genes.
Operate liquid-handling platforms and associated laboratory automation, emphasizing accuracy, reproducibility, and throughput.
Culture, maintain, and experimentally manipulate immortalized, primary, and iPSC-derived cell models.
Perform molecular assays, including RNA isolation, quantitative PCR, digital PCR (dPCR), and protein-based readouts.
Analyze screening data, assess assay quality, identify trends, and communicate results to cross-functional project teams.
Develop, optimize, qualify, troubleshoot, and transfer screening assays, workflows, protocols, and data quality controls to improve efficiency and capabilities.
Collaborate with Platform, Discovery, Chemistry, and Data Science teams to manage screening priorities and advance hits through validation and characterization.
Maintain detailed and accurate records of experimental designs and results, protocols, sample inventories, and data files.
Support routine laboratory operations, including reagent and supply ordering and preparation, equipment maintenance, and general laboratory upkeep.
Take initiative, operate with urgency, and collaborate effectively to advance medicine discovery.