Research Associate II – Antibody Characterization

Twist Bioscience • Quincy, MA

1d • Onsite

About The Position

We are seeking a motivated individual to join our team and expand our antibody characterization department. Using state-of-the-art technologies and workflows, this Research Associate would work with the Antibody Characterization team to ensure project-specific deliverables are met across a diverse panel of discovery campaigns and contract services. The role would involve wet-lab experimental design, execution, and data analysis for multiple custom antibody development projects, incorporating various biologics assay formats.

Requirements

• Bachelor's degree in molecular biology, biochemistry, or a related discipline, and a minimum of 2 years of related experience; or a master’s degree without experience; or equivalent work experience.
• Excellent aseptic technique and experience with mammalian adherent and suspension cell culture are required
• Flow cytometry experience is required
• Ability to troubleshoot scientific processes
• Ability to work independently, but also collaborate and effectively communicate within and across departmental team
• Exceptional written and verbal communication skills
• Highly organized, detail oriented and able to operate in a fast-paced and growing environment

Nice To Haves

• Industry experience strongly preferred.
• Understanding of antibody discovery, preferably focusing on assay development and protein characterization, is preferred
• Previous experience with Carterra, Octet, Hamilton, and/or iQue instruments preferred
• Direct experience with ELISA preferred

Responsibilities

• Performing titer testing, screening, and antibody validation by high-throughput multicolor flow cytometry and ELISA
• Running and troubleshooting cell-based functional assays
• Performing mammalian cell culture, including thaw, maintenance, expansion, cryopreservation, and QC of a wide variety of adherent and suspension cell lines
• Developing, running, and troubleshooting antibody characterization experiments using advanced label-free analytical techniques (e.g., BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning
• Sample handling, sample inventory tracking, and assisting with automation integration into the department
• Concurrently execute multiple antibody discovery projects requiring wet lab activities, data analysis, report generation, and preparation of deliverables adhering to project timelines
• Record and communicate experimental details, draft reports, and deliver data with a high level of integrity and ethics

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level