Manager, Antibody Characterization

Twist Bioscience • Quincy, MA

5d • Onsite

About The Position

This is a management position that provides support for bioanalytical characterization for a variety of therapeutic antibody candidates. This role oversees our Antibody Characterization team and is responsible for managing, optimizing, and troubleshooting a range of workflows, including immunoassays, affinity analysis, functional assays, and target binding characterization.

Requirements

• PhD in a related technical field with 3+ years of management experience in biopharmaceutical analytical development, or MS with 5+ years of experience, including 3+ years of management experience.
• Expert knowledge of biologics characterization assays: extensive hands-on experience required in ELISA, flow cytometry, and SPR/BLI with Carterra and Sartorius Octet.
• Very strong track record of developing, executing, and analyzing common assay formats for biologics discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
• Able to independently manage and prioritize tasks in a fast-paced environment that hinges on overlapping projects and sensitive workflow timelines.
• Advanced understanding of in vivo antibody discovery concepts.
• Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
• Proven management skills for both projects and people, with a strong track record of building trust and developing teams at a variety of levels.
• Exceptional written and verbal communication skills, including customer-facing communication.
• Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.

Responsibilities

• Lead, manage, and develop a team of scientists and research associates in our Antibody Characterization department.
• Provide technical guidance (assay development, analysis, and data reporting) in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), advanced/custom characterization, and functional screening.
• Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
• Review, critically analyze, and present data to customers to facilitate antibody lead selection for a variety of concurrent antibody discovery programs.
• Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
• Work closely with all scientific departments and senior management to ensure excellent management of all activities and effective communication.
• Promote operational and scientific excellence by driving continuous process improvement.
• Stay up to date with recent developments in antibody discovery methods and technologies, and help guide the advancement of our laboratory capabilities in alignment with strategic company goals.
• Spend approximately 30-50% of your time performing wet-lab benchwork alongside the team.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager
• Education Level: Ph.D. or professional degree