QC Technician - RNA/LNP Production

GenScript/ProBio•Redmond, WA

3d•Onsite

About The Position

GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy. GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology. GenScript is a global leader in life sciences research tools and services, providing innovative solutions in gene synthesis, protein expression, antibody development, and cutting-edge mRNA/LNP technologies. Our mRNA & LNP Services team delivers end-to-end solutions for vaccine and therapeutic development — from sequence design and IVT mRNA synthesis to LNP formulation, analytics, and QC release testing. We are seeking a detail-oriented and technically skilled QC Technician to join our rapidly growing mRNA & LNP Service Team. In this role, you will perform analytical testing and quality control assays to ensure the integrity, purity, potency, and consistency of mRNA products and lipid nanoparticle formulations. You will work closely with R&D, Manufacturing team, QA and Project management teams to support client projects and internal process improvements .

Requirements

Bachelor's degree in molecular biology, chemistry, biochemistry, pharmaceutical science or related field, master’s is preferred.
Experience with HPLC, LC-MS, ELISA, cell culture, and flow cytometry is preferred.
Ability to communicate efficiently verbally and in writing.
Ability to perform in a fast-paced environment with high product throughput.
Ability to follow detailed instructions, maintain accurate records and notes, and carry out assignments in a thorough, conscientious fashion while adhering to safe laboratory practices.
A sense of humility and an eagerness to continue to learn and contribute to a supportive team.

Responsibilities

Responsible for supporting communication with production manager and team, contributing to a working environment that encourages employee involvement and collaboration.
Conduct analytical assays including but not limited to: RNA concentration and purity (UV spectrophotometry, fluorometry), RNA integrity (Agilent Bioanalyzer, gel electrophoresis), dsRNA contamination (ELISA, immunoblot, HPLC), LNP particle size and polydispersity (DLS, others), Encapsulation efficiency (ribogreen assay, dye exclusion), Endotoxin testing, pH, osmolality, sterility (as applicable).
Reports out-of-specification results and deviations to the manager. Assists with investigations, root cause analysis, and reports for out-of-specification results and deviations.
Responsible for timely completion of QC report after production job is finished. Accountable for the QC report compliance with good documentation practices.
Support process improvement initiatives within scope of responsibility.
Monitors supply inventory and identifies any products required.
Maintains work area, equipment, department and all storage areas in a clean, neat and orderly manner.
Perform other duties as needed.