About The Position
The Principal Scientist will lead the molecular biology and high-throughput protein production team within the Biologics Production and Engineering group in Boston Discovery Biologics, while providing matrix oversight of automated experimental solutions for the broader organization. The role oversees a production queue that turns protein engineering and hit-identification designs into screening sets of fit-for-purpose therapeutics, and partners with the Early Biotherapeutics Characterization team to coordinate deeper characterization and developability analysis before molecules are released to project teams. The successful candidate will bring deep expertise in designing and executing semi- to fully automated high-throughput approaches for biologics discovery. They will improve workflows, apply drug-discovery experience to advance pipeline programs, and help integrate computational and wet-lab approaches with state-of-the-art automation. As a people manager, the candidate will develop staff, support recruitment, and foster collaboration, accountability, scientific excellence, and inclusion.
Requirements
- Ph.D. in a listed STEM field or related field with 8+ years of relevant industry experience; alternatively, a Master's degree with 12+ years or a Bachelor's degree with 14+ years of relevant industry experience in biochemistry or a related field.
- A record of increasing responsibility and independence in a similar industrial setting.
- Experience supporting biologic therapeutic discovery programs.
- Extensive production-group leadership experience, including talent acquisition, retention, and development.
- Deep expertise in state-of-the-art high-throughput molecular biology and protein-production methodologies.
- Experience developing, adapting, and continuing use of integrated, automated biologic production and characterization platforms, including automated data capture.
- Ability to thrive in a fast-paced, matrixed reporting model while supporting multiple projects in parallel.
- Established external reputation through high-impact publications, presentations, and/or scientific community engagement.
- Demonstrated inclusive behaviors when working with researchers.
Nice To Haves
- Therapeutic project leadership experience resulting in candidate selection and beyond.
- Experience with protein therapeutics beyond antibodies, including higher-valency and complex Fc-containing therapeutics, fusion proteins, and antigens.
- Leadership experience designing and deploying integrated walkaway automated biologic production and characterization platforms.
Responsibilities
- Provide scientific and strategic leadership to a team of 4 FTEs.
- Lead continuous improvement of physical and digital workflows and guide expansion of automated workflows.
- Manage outsourcing CROs for molecular biology and protein production to maximize internal resources.
- Partner effectively with teams within Discovery Biologics and across multidisciplinary interfaces to achieve organizational objectives.
- Manage liquid-handler equipment and associated peripheral equipment, including Dynamic Devices, TECAN, and Hamilton systems.
- Support and co-lead Discovery Biologics therapeutic programs in collaboration with Therapeutic Areas.
- Mentor and develop scientists, leverage individual strengths, and build a high-performing, engaged team.
- Stay abreast of external scientific advancements and promote the external reputation of Discovery Biologics.
- Champion an inclusive culture.
- Support recruitment and the growth and development of current and future staff.
Benefits
- Medical, dental, and vision healthcare benefits and other insurance benefits for employees and family.
- Retirement benefits, including 401(k).
- Paid holidays, vacation, and compassionate and sick days.
- Eligible for an annual bonus and long-term incentive, if applicable.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Senior
