Principal Scientist (Director), Translational Medicine - Infectious Diseases

Merck•Boston, MA

6d•$260,300 - $409,700•Hybrid

About The Position

We have an exciting opportunity for a physician-scientist to join our group as a Principal Scientist (Clinical Director) in Translational Medicine/Early Clinical Development in the Infectious Diseases Therapeutic Area. Translational Medicine at our Research Division is responsible for early clinical development of novel therapeutics, working in close collaboration with our discovery scientists and late-stage clinical researchers. The Infectious Diseases Therapeutic Area specifically focuses on translational and clinical development of anti-infectives, both for treatment and for prophylaxis indications. We are seeking a highly qualified individual for a position in our group. Candidates must have a strong background in basic and/or clinical translational research and a desire to work collaboratively with functional area partners across therapeutic areas and stages of development. Translational Medicine is specifically responsible for: Contributing to the identification of novel targets by partnering with Discovery Sciences to bring a clinical perspective into the earliest stages of target identification and validation, and to execute clinical studies to evaluate the relevance of potential targets to human disease in order to justify full development. Leadership of the early clinical development strategy for novel therapeutic programs from the preclinical stage through Phase 1 studies of safety, tolerability, pharmacokinetics and pharmacodynamics, to Phase 2 studies demonstrating Proof-of-Concept and enabling Phase 3 clinical trials. Development of biomarker strategies through cross-functional teams that advance therapeutics from First-in-Human studies through clinical Proof-of-Concept. This includes experimental medicine studies to establish and/or validate biomarker platforms. Development and execution of clinical pharmacology strategies to support later stages of development, from Phase 3 through to worldwide regulatory applications. Success depends on the integrity, knowledge, imagination, creativity, skill, versatility and teamwork of the people in the group. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork.

Requirements

MD or MD/PhD
Clinical Research
Early Clinical Development
Infectious Disease
Translational Medicine

Nice To Haves

Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
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Responsibilities

Working with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets, including the design of preclinical and clinical experiments to validate targets and/or pathways, and leveraging this work for development of novel therapeutics
Working with cross-functional teams including discovery scientists, pharmacologists, toxicologists, and other specialists to advance novel therapeutics from preclinical development into clinical development
As a key member/leader of an early development team, working in close collaboration with internal and external staff and scientists (including discovery research, biostatistics, drug metabolism, modeling and simulation, regulatory affairs, and global clinical trials operations) for the design and execution of early clinical development strategy
Taking a lead role in developing and executing clinical pharmacology studies for programs in all phases (I – IV) of development, including formulation or device changes, drug-drug interaction studies, and studies in special populations
Providing early phase/clinical pharmacology support for programs through the regulatory filing process including preparation of supportive documents and presentations
Developing and executing studies to validate established and novel clinical biomarkers, including blood/tissue sampling, imaging, electrophysiological, wearable devices, and behavioral responses to study biological activity in humans
Providing clinical and scientific expertise to assess internal and external opportunities for partnership
Engaging with the broader internal and external scientific community in disease or therapeutic areas of interest, including via consultations with scientific/academic thought leaders, preparation of posters and publications, and attendance/presentation at conferences
Working broadly with key functions across the company at research sites around the world.