Principal Research Scientist I – Analytical Development – PDST – Late-Stage Process Analytics

AbbVie•Waltham, MA

24d•$124,500 - $236,500•Onsite

About The Position

The Principal Scientist I will be an integral part of the Process Analytics team in the Operations – Product Development Science and Technology – Biologics division. The role involves leading analytical activities within a high-throughput testing group supporting biologics products with a focus on advancing AbbVie’s late-stage clinical programs. This position calls for an individual with a strong technical analytical background, demonstrated leadership and organizational skills and the ability to effectively communicate and work cross-functionally.

Requirements

PhD in chemistry, biology, biochemistry, chemical engineering, or related technical discipline with 6+ years of relevant professional experience working in analytical development or process analytics; MS degree with minimum of 10+ years of relevant experience.
Proven experience leading analytical development activities for biologics development, including mAbs, multi-specifics, antibody-drug conjugates, and fusion proteins.
Hands on method development experience in protein and impurity analysis techniques such as HPLC, capillary electrophoresis, and other relevant methods for biologics required.
Highly organized with ability to multitask and drive efficient workflows.
Ability to think critically and demonstrate troubleshooting and problem-solving skills.
Strong people leadership skills and demonstrated ability to foster an engaging, inclusive and collaborative team environment. Direct people management experience required.
Excellent communication and interpersonal skills. Ability to work effectively across functions, anticipating and addressing overall program development needs.
An independent, self-motivated, proactive individual who thrives in a fast-paced team environment.

Nice To Haves

Experience with mass spectrometry and ELISA is a plus.
Previous experience with automation is a plus.

Responsibilities

Lead analytical activities within a high-throughput testing group supporting biologics process development for late-stage programs.
Serve as the subject matter expert for separation-based methods, including HPLC and capillary electrophoresis.
Evaluate and select effective fit for purpose analytical technologies and methods to meet process development needs.
Provide expertise and support for method development, execution, and troubleshooting. Provide direct technical guidance and oversight to scientists executing sample testing with hands on lab support when needed.
Partner with process development SMEs for interpretation and understanding of analytical data.
Oversee sample testing schedule and prioritization; drive timely delivery of high-quality testing results.
Support implementation of automation and high-throughput experimentation workflows.
Drive continuous improvement initiatives to enhance lab efficiency and capability.
Mentor, train and supervise junior scientists.