Principal Manager, Clinical Operations Lead

Immatics • Houston, TX

5d • $165,000 - $180,000 • Remote

About The Position

Immatics is seeking a Principal Manager, Clinical Operations Lead to support its Clinical Operations team. The role oversees, executes, and operationally manages US regional clinical trials in support of clinical development programs. The position leads trial delivery from study start-up through execution, working with internal teams, CROs, vendors, and other clinical trial partners to meet quality, compliance, timeline, and budget objectives. It also contributes to risk management, process improvement, inspection readiness, and the development of Clinical Operations team members. The role is fully remote in the United States and reports to the Associate Director, Clinical Asset Management. The stated salary range is $165,000–$180,000. Applicants must be authorized to work in the United States without current or future sponsorship. Employment is contingent on applicable pre-employment screening.

Requirements

• Bachelor’s degree in life science, nursing, or a similar field.
• At least 7 years of demonstrated leadership of global clinical operations in the pharmaceutical or biotechnology industry, including clinical trial oversight, vendor management, and cross-functional study leadership.

Nice To Haves

• Master’s degree, preferably in life science, nursing, or a similar field.
• Experience in late-phase oncology or launch.
• Experience with cell and/or gene therapy, or other complex biologic clinical development programs.
• Demonstrated ability to drive process improvements and operational excellence initiatives.
• Ability to understand and navigate complex clinical development processes and cross-functional interdependencies, and to collaborate with stakeholders outside Clinical Operations.
• Strong analytical and problem-solving skills, including the ability to assess operational impact across broader cross-functional environments.
• Ability to operate effectively in a fast-paced and evolving clinical research environment.

Responsibilities

• Lead clinical trial execution and operational delivery across internal and external stakeholders from study start-up through execution.
• Oversee CROs, vendors, and clinical trial partners to ensure quality, compliance, timelines, and budget objectives are achieved.
• Serve as the Clinical Operations leader for CTMs, CRAs, and CTAs assigned to each project.
• Drive risk identification, issue escalation, and mitigation planning across assigned studies.
• Support study start-up, site feasibility, enrollment, and operational execution activities.
• Partner with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain, Program Leadership, and external vendors.
• Contribute to SOP development, process optimization, inspection readiness, and operational excellence initiatives.
• Mentor and coach junior Clinical Operations team members as applicable.

Benefits

• Competitive health, dental, and vision insurance rates.
• Four weeks of vacation granted up front each year, prorated for the first and last year of employment.
• 12 company-paid holidays.
• 7 days of sick time.
• 100% employer-paid life insurance coverage up to 1x annual salary, capped at $100,000.
• 100% employer-paid short- and long-term disability coverage.
• 401(k) with immediate eligibility and company match: 100% of contributions up to 3% of base salary for the first two years, 4% for years 2–3, and up to 5% from the fourth year onward.
• Partially paid parental leave for eligible employees.
• Optional employee-paid benefits and services, including accident, hospital indemnity, critical illness, identity theft protection, and pet insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior