Principal Investigator (MD/DO)

ALLIANCE CLINICAL LLC•Denver, CO

41d•Onsite

About The Position

Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to help build a new clinical research site from the ground up in Denver, CO. As the Principal Investigator, you will provide clinical and medical guidance as the site establishes itself and grows its research portfolio. This role offers the opportunity to make an impact without the demands of a traditional full-time clinical practice, providing a more predictable schedule and the chance to fully contribute time to clinical research. It's an attractive opportunity for physicians who enjoy medicine and clinical research and want to remain clinically engaged.

Requirements

MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
Active, unrestricted Colorado medical license
Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
Strong clinical judgment and commitment to participant safety
Interest in clinical research and advancing medical innovation
Comfort reviewing structured clinical data and study-specific medical information
Strong communication, documentation, and confidentiality practices
Familiarity with ICH-GCP and FDA clinical research regulations
Board certification
DEA registration, if required by applicable study protocols

Responsibilities

Provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.
Serve as the study physician and provide medical oversight for assigned clinical trials.
Protect the safety, rights, and well-being of research participants throughout the study.
Review and confirm participant eligibility and provide medical oversight of screening outcomes.
Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
Serve as a clinical resource for study-related medical questions and safety concerns.
Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
Support timely safety reporting, medical documentation, and resolution of clinical data queries.
Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
Contribute to a culture of quality, continuous improvement, and patient-centered research.