Principal Associate Scientist, Analytical Development & Operations

Strand Therapeutics•Boston, MA

6d•$105,000 - $114,000

About The Position

Strand Therapeutics is seeking a highly motivated and innovative Principal Associate Scientist for Analytical Development & Operations. The role is suited to a scientist with a strong scientific foundation and experience in mRNA/Lipid Nanoparticle (LNP) technologies, process development or characterization, and/or analytical development. Working at the interface of process and analytical development, the scientist will use analytical data to build process understanding and evaluate how process parameters and material attributes affect product quality. The position reports to the Principal Scientist of Analytical Development and contributes to a matrix-based team in a fast-paced, early-stage company environment. The scientist will lead analytical method development and novel techniques for deep physical characterization of early- and clinical-stage mRNA and LNP formulations; analyze results to guide screening, optimization, and scale-up; and work with cross-functional CMC partners and external research organizations. The role includes conducting laboratory experiments, maintaining electronic notebook records, authoring protocols, and mentoring junior scientists.

Requirements

B.S. or advanced degree in Chemistry, Chemical Engineering, Biology, Biochemistry, Molecular Biology, or another relevant scientific discipline.
At least 5 years of experience in Analytical and Process Development, preferably focused on mRNA and/or LNP technology.
Working knowledge of common mRNA/LNP analytical methods, such as plate-based assays, PCR, UPLC/HPLC, light scattering, and/or capillary gel electrophoresis.
Working experience in analytical method development.
Experience with enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies.
Ability to conduct laboratory experiments and strong documentation review and writing skills.
Flexibility to work on multiple projects as needed.
Ability to adapt quickly to change and thrive in a dynamic, entrepreneurial early-stage environment.
Strong teamwork, oral and written communication skills, and demonstrated ability to work independently.
Self-motivation, attention to detail, and good problem-solving ability.

Nice To Haves

Familiarity with advanced analytical technologies such as LC-MS, in-line monitoring, automation, digital process development, and/or advanced data analysis techniques.
Understanding of process development and/or regulatory aspects of mRNA-(lipid) nanoparticle products.

Responsibilities

Lead development of analytical methods or novel analytical techniques focused on deep physical characterization of early- and clinical-stage mRNA and LNP formulations.
Analyze data and draw conclusions to guide screening, optimization, and scale-up efforts in mRNA and LNP Process Development.
Apply knowledge of mRNA and LNP analytical methods to support identification and characterization of critical process parameters and critical material attributes.
Independently troubleshoot experimental and process challenges using a systematic, data-driven approach.
Partner with Process Development, Manufacturing, MSAT, Quality, and other CMC functions to support process development and characterization.
Evaluate and onboard innovative analytical tools to advance RNA/LNP understanding.
Interface with external contract research organizations to ensure internal timeline and quality requirements are met.
Mentor and develop junior scientists in exploring analytical techniques for further characterization of mRNA/LNP therapeutics.
Maintain electronic notebook records and author protocols.
Conduct laboratory experiments and review and write documentation.