Principal Associate Scientist, Analytical Development & Operations

Strand Therapeutics•Boston, MA

5d•Onsite

About The Position

Strand Therapeutics is seeking a highly motivated and innovative Principal Associate Scientist for Analytical Development & Operations. The role works at the interface of process and analytical development, using analytical data to build process understanding and evaluate how process parameters and material attributes affect product quality. The successful candidate will contribute to a small, productive team in a matrix-based environment and help shape the company’s future strategy. The position reports to the Principal Scientist of Analytical Development. The scientist will develop analytical methods and techniques for deep physical characterization of early- and clinical-stage mRNA and lipid nanoparticle (LNP) formulations, and use the resulting data to support screening, optimization, and scale-up efforts. The role collaborates across CMC functions and external organizations, evaluates new analytical tools, and helps develop junior scientists. Laboratory experimentation, documentation, and work across multiple projects are part of the position.

Requirements

B.S. or advanced degree in Chemistry, Chemical Engineering, Biology, Biochemistry, Molecular Biology, or another relevant scientific discipline.
At least 5 years of experience in Analytical and Process Development, preferably focused on mRNA and/or LNP technology.
Working knowledge of common mRNA/LNP analytical methods, such as plate-based assays, PCR, UPLC/HPLC, light scattering, and/or capillary gel electrophoresis.
Experience with analytical method development.
Experience with enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies.
Ability to conduct laboratory experiments and demonstrate excellent documentation review and writing skills.
Flexibility to work on multiple projects as needed.
Ability to adapt quickly to change and thrive in a dynamic, entrepreneurial early-stage environment.
Strong teamwork, oral and written communication, and independent working skills.
Motivation, attention to detail, and good problem-solving ability.

Nice To Haves

Familiarity with advanced analytical technologies such as LC-MS, in-line monitoring, automation, digital process development, and/or advanced data analysis techniques.
Understanding of process development and/or regulatory aspects of mRNA-(lipid) nanoparticle products.

Responsibilities

Lead development of analytical methods or novel analytical techniques for deep physical characterization of early- and clinical-stage mRNA and LNP formulations.
Analyze data and draw conclusions to guide screening, optimization, and scale-up efforts in mRNA and LNP Process Development.
Apply knowledge of mRNA and LNP analytical methods to support identification and characterization of critical process parameters and critical material attributes.
Independently troubleshoot experimental and process challenges using a systematic, data-driven approach.
Partner with Process Development, Manufacturing, MSAT, Quality, and other CMC functions on process development and characterization activities.
Evaluate and onboard innovative analytical tools to improve RNA/LNP understanding.
Coordinate with external contract research organizations to ensure internal timeline and quality requirements are met.
Mentor and develop junior scientists exploring analytical techniques for characterization of mRNA/LNP therapeutics.
Maintain electronic notebook records and author protocols.
Conduct laboratory experiments and support multiple projects as needed.