Postdoctoral Scientist -Surgery Chair, Jevtic Lab
About The Position
The Jevtic laboratory aims to understand how the ubiquitin-proteasome system (UPS) regulates gene expression and cell fate, and how disruptions in these pathways contribute to human diseases. A key focus is the E3 ubiquitin ligase SCF-FBXL14 and its interaction with Groucho/TLE transcriptional co-repressors. TLEs are crucial for development and are often altered in cancer. SCF-FBXL14, through its association with TLEs, regulates numerous transcription factors that govern tissue development. The lab investigates how the UPS manages repressive protein complexes on chromatin to allow for dynamic gene expression changes and proper cellular identity. They utilize human stem cell and cancer models combined with genomic, proteomic, biochemical, and structural approaches. By integrating this research with the clinical expertise and resources at Cedars-Sinai, the goal is to discover how defects in ubiquitin-dependent gene expression control cause disease and to develop new therapeutic strategies.
Requirements
- Doctorate Degree, Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization required.
- Demonstrated ability to design experiments, analyze data, and communicate scientific findings effectively.
- Highly motivated and works independently on research projects designed by a mentor (typically the PI) within the area of specialization.
- Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
- Highly motivated with a proven track of record of publications.
- Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, and operation and maintenance of specialized equipment.
- Knowledge of safety standards and maintenance of specialized equipment.
Nice To Haves
- Doctorate (PhD, MD/PhD) in relevant scientific or engineering field highly preferred.
- Experience in biochemistry, cell biology, cancer biology, or related fields is preferred.
- Experience in Genomics, Protein purification and Biochemistry highly preferred.
Responsibilities
- Designs and performs experiments.
- Keeps appropriate experimental records and documentation.
- Analyzes the results with the Principal Investigator.
- May develop, adapt, and implement new research techniques and protocols.
- Analyzes, interprets, summarizes, and compiles data.
- Performs routine and complex laboratory procedures.
- Operates and maintains equipment and instruments.
- May observe MD-patient or MD-human research subject interactions as it pertains directly to research being performed.
- May assist in the preparation of grant proposals, but is not responsible for generating grant funds.
- May participate in publications and presentations as author or co-author.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
