Postdoctoral Scholar - Penn State Biomedical Engineering

Penn State University•University Park, IL

6d•Onsite

About The Position

The Pritchard Lab in the Department of Biomedical Engineering at the Pennsylvania State University is seeking to fill a Postdoctoral Scholar position. The scholar will lead in vivo mouse studies at the interface of evolution, synthetic biology, and targeted therapy, supporting an NIH-funded program (5 year grant) that develops "selection gene drives," a regulated gene therapy that partners with standard-of-care targeted therapies to overcome drug resistance. The successful candidate will design and execute efficacy and safety studies across cell line-derived xenograft (CDX), orthotopic, patient-derived xenograft (PDX), and immune-competent syngeneic models, including intravenous vector delivery, in vivo imaging (IVIS, micro-CT), and pharmacokinetic, pharmacodynamic, and toxicology cohorts.

Requirements

Ph.D. by the time of appointment in Biomedical Engineering or a related scientific field.
Extensive hands-on experience with mouse tumor models.
Extensive hands-on experience with in vivo techniques including IP, IV and SC injections, and oral gavage.
Proficiency in modern molecular biology techniques.
Submit a CV that includes a list of education, publications, and work experience.

Responsibilities

Lead in vivo mouse studies at the interface of evolution, synthetic biology, and targeted therapy.
Design and execute efficacy and safety studies across cell line-derived xenograft (CDX), orthotopic, patient-derived xenograft (PDX), and immune-competent syngeneic models.
Conduct intravenous vector delivery.
Perform in vivo imaging (IVIS, micro-CT).
Manage pharmacokinetic, pharmacodynamic, and toxicology cohorts.