Postdoctoral Scholar - Cell and Biological Systems

Penn State University•Tallahassee, FL

2d•Onsite

About The Position

The College of Medicine, Department of Cell and Biological Systems is seeking a postdoctoral scholar position in Dr. Shengyu Yang’s lab in Hershey, PA to study the role of mitochondrial metabolism and metabolic stress signaling in cancer metastasis. Our goal is to reveal how the mitochondrial metabolism and nutrient stress controls metastatic progression through epigenetic remodeling. This project is built on our recent discoveries that the actin cytoskeleton remodeling in metastatic cancer cells is able to control mitochondrial metabolism through regulating the homeostasis of mtDNA and the biogenesis of mitochondrial respiratory chain. Biochemistry, cell biology, genetically engineered mouse models and patient-derived organoids / xenografts will be employed in the study. The research in Dr. Yang’s lab is funded by grants from the National Cancer Institute, National Institute on Aging and Department of Defense. Penn State College of Medicine Campus is located in Hershey, PA. Hershey is a quiet, family friendly town with affordable living expense and easy access to major metropolitan areas (e.g. Philadelphia, Washington DC, New York City).

Requirements

Ph.D. or equivalent degree.
Expertise in biochemistry, molecular biology, cancer metabolism, or related fields.
Highly motivated individual.

Nice To Haves

Experience with genetically engineered mouse models.
Experience with Next Generation Sequencing data analysis.

Responsibilities

Study the role of mitochondrial metabolism and metabolic stress signaling in cancer metastasis.
Reveal how mitochondrial metabolism and nutrient stress control metastatic progression through epigenetic remodeling.
Employ biochemistry, cell biology, genetically engineered mouse models, and patient-derived organoids/xenografts in the study.