POSTDOCTORAL RESEARCHER - Gene Regulation and Functional Genomics - Kraus Lab [Req#: 972110, Position#: 133457]
About The Position
A postdoctoral training position is available in the laboratory of W. Lee Kraus, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center. We are seeking highly motivated candidates to investigate fundamental mechanisms of signaling and gene regulation, with a particular emphasis on transcriptional control, chromatin dynamics, and functional genomics in physiology and diseases. Our laboratory is interested in a wide variety of model systems and experimental approaches, including biochemistry, molecular biology, structural biology, animal models, genomics, proteomics, bioinformatics, and computational biology to uncover how signaling pathways control gene expression programs, spanning multiple interconnected areas: (1) signaling by NAD + and steroid hormones; (2) ADP-ribosylation and the PARP enzymes that catalyze this modification in transcription, translation, chromatin dynamics, and RNA biology; (3) enhancer function and enhancer RNA regulation in gene activation; (4) RNA-based mechanisms in nuclear signaling and gene regulation; and (5) systems-level approaches to map signaling-gene regulation networks across the genome and transcriptome, with applications to cancer, metabolism, development, and a variety of human diseases. This position offers the opportunity to lead innovative, high-impact projects in a collaborative and well-resourced research environment at UT Southwestern. Information on our postdoctoral training program, benefits, and a virtual tour can be found at http://www.utsouthwestern.edu/postdocs.
Requirements
- Hold a recent Ph.D. and/or M.D. degree.
- Experience in gene regulation, genomics, chromatin biology, molecular biology, cell biology, and related fields.
- Strong record of productivity, including publications in peer-reviewed journals.
Nice To Haves
- Expertise in next-generation sequencing approaches (e.g., RNA-seq, ChIP-seq).
- Expertise in genome editing.
- Expertise in computational genomics.
Responsibilities
- Investigate fundamental mechanisms of signaling and gene regulation.
- Focus on transcriptional control, chromatin dynamics, and functional genomics in physiology and diseases.
- Utilize a wide variety of model systems and experimental approaches, including biochemistry, molecular biology, structural biology, animal models, genomics, proteomics, bioinformatics, and computational biology.
- Uncover how signaling pathways control gene expression programs.
- Conduct research in areas including signaling by NAD+ and steroid hormones, ADP-ribosylation and PARP enzymes, enhancer function and regulation, RNA-based mechanisms in nuclear signaling, and systems-level approaches to map signaling-gene regulation networks.
- Apply research findings to cancer, metabolism, development, and human diseases.
- Lead innovative, high-impact projects.
Benefits
- Postdoctoral training program
- Benefits information available at http://www.utsouthwestern.edu/postdocs
- Virtual tour available at http://www.utsouthwestern.edu/postdocs
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
