Postdoctoral Research Fellow

University of British Columbia • Vancouver, BC

3d • CA$65,000 - CA$75,000 • Onsite

About The Position

Endometriosis Oncogenomics and Pathology Research Lab (EDGE Research) at the University of British Columbia is seeking a highly motivated Postdoctoral Fellow to study the process driving malignant transformation of endometriosis to clear cell and/or endometrioid ovarian carcinomas. This work will form the basis of prevention, treatment, and etiological understanding of disease. The successful candidate will work within a multidisciplinary team integrating molecular biology, genomics, epigenomics, microbiome science, proteomics, and clinical research. The position will focus on the development and evaluation of low-input whole genome sequencing and study of genotoxic stress markers. This project is funded through a four-year US Ovarian Cancer Research Program grant. This is an on-site position located at Vancouver Hospital Campus.

Requirements

• PhD in molecular biology, translational research, genomics, bioinformatics, proteomics, cancer biology, reproductive biology, or a related field.
• Experience with at whole genome next-generation sequencing analysis and related approaches is needed.
• Strong understanding of molecular pathology and biomarker development.
• Excellent organizational skills and attention to detail.
• Demonstrated ability to manage complex projects and work independently.
• Demonstrated commitment to research reproducibility and rigorous scientific practices.
• Excellent written communication skills, including experience assisting with grant writing, manuscripts, and scientific reports.

Nice To Haves

• Experience in gynecologic cancer genomics is an asset.
• Experience working with clinical specimens.
• Experience integrating multiple data types within translational research projects.
• Familiarity with women's health, reproductive biology, gynecologic cancers, and microbiome research.
• Experience collaborating across multidisciplinary teams.
• Flexible to travel to international conferences and collaborating sites in Canada, the US, and overseas.
• Eligibility for post-doctoral funding from MITACS (Elevate) and/or Canada Postdoctoral Research Award program (CPRA)

Responsibilities

• Project management and co-ordination of incoming specimen including maintaining ethics, operational approvals, and relationships with contributing hospitals.
• Support assay development and validation activities involving cellular and genotoxic stress, predominantly IHC/IF based assays.
• Lead review and enrichment (laser capture) of endometriosis, cancer, and control tissues for whole genome sequencing including co-ordination of external sequencing contracts and bioinformatics.
• Contribute to study design, data interpretation, quality control, and experimental troubleshooting.
• Lead genomic analysis and integration of multi-omics data including microbiome and cell stress phenotypes.
• Lead collaboration with spatial transcriptomics and functional genomics team (external). Assist with the development and optimization of laboratory and analytical workflows.
• Contribute to grant applications, manuscripts, reports, and presentations, with strong scientific writing skills and attention to reproducibility.
• Collaborate with clinicians, laboratory scientists, trainees, and external partners. This will include supervision, training and recruitment of junior trainees (e.g. undergraduate, and graduate students involved with aspects of the project)

Benefits

• extended health

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree