Postdoctoral Research Associate – Genome Instability in Cancer

UVA Health•Charlottesville, VA

9d•Onsite

About The Position

The Tang Lab at the University of Virginia School of Medicine is seeking a highly motivated Postdoctoral Research Associate with a background in cellular and molecular biology. Our research focuses on the molecular mechanisms of R-loop regulation, DNA-protein crosslinks (DPCs), and their contributions to genome instability in cancer and congenital human disorders. Current research interests include R-loop biology and transcription-replication conflicts (TRCs), DNA-protein crosslink (DPC) formation, repair, and consequences, genome instability mechanisms in cancer and congenital disorders, and the development of novel tools for locus-specific chromatin and R-loop interrogation. The ultimate goal is to elucidate the molecular mechanisms by which R-loops and DPCs drive genome instability, with the potential to inform the development of novel therapeutics for related human diseases. This is a full-time research or scholarship position at the University, preparatory for a full-time academic or research career. The appointee will be supervised by a senior scholar and allowed to publish the results of their research or scholarship. Other duties may be assigned.

Requirements

Doctoral degree, preferably PhD in Cell Biology, Genetics and Genomics, Biochemistry, Molecular Biology, or a related Biomedical Science discipline.
Awarded a doctoral degree within the previous five years.
Resume
Cover Letter
Contact information for three professional references

Nice To Haves

First-author publication(s) in high-impact peer-reviewed journals.
Prior experience with live-cell imaging.
Prior experience with genomics.
Prior experience with protein expression and purification.

Responsibilities

Conduct research on R-loop biology and transcription-replication conflicts (TRCs).
Investigate DNA-protein crosslink (DPC) formation, repair, and consequences.
Study genome instability mechanisms in cancer and congenital disorders.
Develop novel tools for locus-specific chromatin and R-loop interrogation.
Publish the results of research or scholarship.
Perform other duties as assigned.