Postdoctoral Fellowship in Structural Mass Spectrometry

MB-Molecular Biophys & Integ Bio • Berkeley, CA

4d • Onsite

About The Position

Berkeley Lab’s ( LBNL ) Molecular Biophysics and Integrated Bioimaging Division ( MBIB ) has an opening for a Postdoctoral Fellow to conduct structural characterization of antibody-antigen complexes using the method of X-ray footprinting mass spectrometry. In this exciting role, you will help develop a rapid pipeline for epitope and paratope mapping, with the goal of providing fast response to emerging viral threats. You will work closely with structural biology scientists primarily in the area of X-ray footprinting and interface with experts in small angle X-ray scattering and protein crystallography. You will present results to project team members, the wider scientific community, and be expected to prepare first-author research papers. You will have the opportunity to learn new structural biology methods and help determine future research directions for the group. This position has an anticipated start date of March 3, 2025.

Requirements

• A recent Ph.D. (within the last 1-2 years) in Biochemistry, Chemistry, Molecular Biology, Bioengineering or a related discipline.
• Experience with molecular biology including wet lab skills in handling and preparing protein samples.
• Experience running LCMS data acquisition, analyzing LCMS peptide, and/or protein data.
• Experience with basic protein characterization methods such as CD and UV-vis.
• Demonstrated analytical skills including solving problems, developing scientific ideas, and meeting research goals.
• Strong organizational skills including experience maintaining detailed and accurate records of experiment results and analyzed data.
• Excellent oral and written communication skills including experience organizing/presenting technical reports, successful record of first-author publications, and presenting at conferences.
• Demonstrated interpersonal skills including experience conducting experiments independently and collaborating with a diverse interdisciplinary research team.

Nice To Haves

• Expertise in proteomics.

Responsibilities

• Prepare and process samples for X-ray irradiation using standard molecular biology methods such as gels, buffer dialysis, and enzymatic digestion.
• Perform X-ray irradiation at the Advanced Light Source (ALS) X-ray footprinting beamline.
• Perform Liquid Chromatography Mass Spectrometry (LCMS) on digested protein samples.
• Develop and troubleshoot new LCMS methods as needed.
• Keep an accurate and detailed laboratory notebook and tracking spreadsheets.
• Communicate research progress within the groups and report results externally through conference presentations and peer-reviewed publications.

Benefits

• competitive compensation program
• excellent health and welfare programs
• a retirement program that is second to none
• outstanding development opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree