Postdoctoral Fellow - Protein Sciences, Ciferri Lab

Roche • South San Francisco, CA

1d • $100,000 - $106,500 • Onsite

About The Position

A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join our Protein Sciences - Structural Biology Group at Genentech, under the mentorship of Dr. Claudio Ciferri, Vice President of Protein Sciences. The Fellow will investigate the structure and mechanism of action of critical protein complexes involved in DNA repair and RNA regulation. Our ideal candidate is a self-motivated researcher who already has specific, independent project ideas they are eager to develop and lead from day one. The Department of Structural Biology within Protein Sciences is a world-leading research and drug discovery organization focusing on cutting-edge biomedical questions. You can pursue challenging and important problems that aim to uncover fundamental biological mechanisms that would advance our understanding of human physiology in health and disease. You will have access to fully equipped with state-of-the-art facilities, including two Titan Krios & two Glacios microscopes equipped with Direct Detectors and Energy Filters, a virtually unlimited computer cluster for data processing, and have the opportunity to be fostered in one of the most productive and scientifically stimulating research environments. You will be part of Genentech's post-doctoral training program that provides an outstanding environment and the opportunity to pursue fundamental basic science questions in an environment focused on drug discovery and breakthrough discoveries.

Requirements

• Ph.D. in structural biology, biochemistry, molecular biology, or a related field or be scheduled to receive a Ph.D. by 2026.
• Expertise in protein purification, biophysical characterization, and structure determination of multi-protein complexes using X-ray crystallography and/or single-particle cryo-EM.
• Strong record of first-author publications in top peer-reviewed journals.
• Highly motivated and detail-oriented researcher, driven to solve complex scientific problems.
• Able to work both independently and in a collaborative environment.
• Strong oral and written communication skills.

Nice To Haves

• Experience in protein engineering.
• Experience with biophysical characterization methods for protein-protein interactions, such as surface-plasmon resonance (SPR) or bio-layer interferometry (BLI).

Responsibilities

• Investigate the structure and mechanism of action of critical protein complexes involved in DNA repair and RNA regulation.
• Develop and lead independent project ideas from day one.
• Pursue challenging and important problems that aim to uncover fundamental biological mechanisms that would advance our understanding of human physiology in health and disease.
• Conduct world-class research.
• Publish in top-tier journals.
• Build a robust scientific network.

Benefits

• Competitive salaries
• Fully funded research expenses
• Access to world-class seminars
• Professional development workshops
• Networking opportunities
• Relocation benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree