Postdoctoral Fellow - Biocatalysis

Amgen • Thousand Oaks, CA

10d

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Postdoctoral Fellow - Biocatalysis What you will do Let’s do this. Let’s change the world. In this vital role you will be responsible for developing and optimizing manufacturing routes to small molecule and hybrid drugs in Amgen’s pipeline. This 2-year fellowship will be focused on the development of AI/ML-based tools for the discovery and engineering of biocatalysts within DS manufacturing routes. Seeking start date Q4 of 2026 or Q1 of 2027 Interact and collaborate with scientists across various Amgen functions Apply cutting edge protein design tools to biocatalyst design Develop and train models for (1) enzyme discovery from metagenomic databases and (2) active learning through enzyme evolution campaigns Publish application of developed models on model systems

Requirements

• PhD at time of appointment.

Nice To Haves

• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)
• Demonstrated strong communication skills, ability to multi-task and work collaboratively in a cross-functional team environment
• Experience with enzyme design and computation prediction for biocatalysis
• Experience with protein language models, structure-based protein design (e.g. proteinMPNN), or other recent developments in ML for protein design
• Experience with collaborative deep learning workflows, including developing code using PyTorch and managing version control and code reviews via Git
• PhD in computational biology, computational chemistry, machine learning, or related field

Responsibilities

• Developing and optimizing manufacturing routes to small molecule and hybrid drugs in Amgen’s pipeline.
• Development of AI/ML-based tools for the discovery and engineering of biocatalysts within DS manufacturing routes.
• Interact and collaborate with scientists across various Amgen functions
• Apply cutting edge protein design tools to biocatalyst design
• Develop and train models for (1) enzyme discovery from metagenomic databases and (2) active learning through enzyme evolution campaigns
• Publish application of developed models on model systems

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree