Postdoctoral Associate, Pulmonary Center, Department of Medicine

Boston University • Boston, MA

7d • $67,500 - $75,000 • Onsite

About The Position

The Department of Medicine at Boston University, Bosmann Laboratory, is recruiting highly motivated Postdoctoral Fellows to work on projects in Immunology and Host–Pathogen Interactions. The immune system protects against invading pathogens and opportunistic microbes at barrier surfaces such as the lung and gut. Dysregulation of these interactions plays a critical role in bacterial infections (including pneumonia and sepsis) as well as inflammatory bowel disease. In the absence of fully effective therapeutic options, these microbe-driven inflammatory diseases represent a major and growing burden on health care systems worldwide. Our laboratory is dedicated to achieving a mechanistic understanding of the molecular pathogenesis of bacterial infections and host–pathogen interactions, with the goal of identifying and evaluating novel therapeutic targets. A particular emphasis is placed on novel genes, for which our laboratory has generated multiple genetically engineered mouse models. We seek outstanding postdoctoral candidates with strong career potential to advance our experimental and translational research programs. Depending on the interests and background of the trainee, projects may focus on IBD-related mucosal immunity or on pneumonia and sepsis, or on shared immune mechanisms across these disease contexts. The research environment offers access to a broad spectrum of state-of-the-art immunological techniques, including single-cell transcriptomics (scRNA-Seq, TOTAL-Seq) and phospho-/proteomics. Data analysis is supported by an experienced bioinformatician within the laboratory.

Requirements

• Highly motivated postdoctoral candidates with strong career potential.
• Background in Immunology and Host–Pathogen Interactions.
• Experience with experimental and translational research.
• Familiarity with immunological techniques.
• Ability to analyze data.

Nice To Haves

• Experience with single-cell transcriptomics (scRNA-Seq, TOTAL-Seq).
• Experience with phospho-/proteomics.
• Experience with genetically engineered mouse models.
• Interest in bacterial polyphosphates in immunity at barrier organs.
• Interest in innate immune cells (macrophages, neutrophils, T cells).
• Interest in cytokine biology and immune signaling pathways (e.g., G-protein signaling).
• Familiarity with pathogens such as Escherichia coli, Streptococcus pneumoniae, Legionella spp.

Responsibilities

• Conduct research projects in Immunology and Host–Pathogen Interactions.
• Investigate bacterial infections and host–pathogen interactions.
• Identify and evaluate novel therapeutic targets.
• Generate and utilize genetically engineered mouse models.
• Focus on IBD-related mucosal immunity, pneumonia, sepsis, or shared immune mechanisms.
• Utilize state-of-the-art immunological techniques such as single-cell transcriptomics and phospho-/proteomics.
• Analyze data with support from a bioinformatician.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree