Post-Doctoral Fellow

University of Colorado • Aurora, CO

1d • Onsite

About The Position

The Fernández-Mariño lab is seeking to hire a postdoctoral fellow. The position will focus on university compliance, lab organization, and inventory, and has reserved time (approximately 50%) to contribute to other aspects of the lab’s research. These aspects include investigating the molecular mechanisms of membrane proteins using an integrative approach combining biochemistry, biophysics, and structural biology. The lab is looking for a creative and motivated scientist interested in understanding how changes in protein structure control biological function. The project will focus on the biochemical and structural characterization of voltage-gated ion channels and its regulation by nanoantibodies in disease signaling pathways. The lab is located within the University of Colorado School of Medicine Department of Physiology & Biophysics and the Aurora/Denver Anschutz Medical campus. Postdoctoral fellows will benefit from a multidisciplinary, vibrant, open, and collegial department. The Fernández-Mariño lab provides rich opportunities to interact with other biophysics and physology laboratories within the department, also with an even larger collection of systems neuroscience laboratories studying the neural basis of sensory-motor behaviors.

Requirements

• Ph.D. in biochemistry, structural biology, molecular biology, biophysics, neuroscience, or a related field
• A record of first-author publications

Nice To Haves

• Molecular Biology
• Expression and purification of recombinant proteins
• Membrane protein production and characterization
• Protein engineering and biochemical assay development
• Nanobody discovery, selection, characterization
• Structural biology approaches (preferably cryo-EM)
• Biophysical characterization of protein structure
• Experience with membrane proteins and/or nanobody technologies is highly desirable.
• Expertise in structural biology would be a major advantage, but enthusiasm for learning new approaches and addressing challenging biological questions is equally valued.
• Advanced knowledge of laboratory techniques including safety procedures and techniques
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Ability to interpret and master complex research protocol information
• Knowledge on molecular biology
• Knowledge on basic animal anatomy and physiology.

Responsibilities

• Perform experiments and tabulate and analyze research data
• Oral communication of preliminary results at lab meetings
• Oral and written communication of completed work at national or international meetings.
• Create figures and write papers
• Collaborate with and support Principal Investigators (PI) and other stakeholders with laboratory and research functions
• Utilize a variety of laboratory techniques required for research projects
• Independently and creatively identify laboratory solutions
• Independently review, develop and implement new or modified laboratory techniques required for research projects
• Provide laboratory science expertise and leadership in study design, study oversight, data management, data analysis and manuscript preparation to assist all levels of investigators, researchers and clinicians on new research activities across a wide range of disciplines

Benefits

• Comprehensive benefits package
• Generous leave
• Health plans
• Retirement contributions

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree