Post Doctoral Fellow-MSH-32086-003

Mount Sinai Health System • New York, NY

9d • Onsite

About The Position

This training program will provide advanced expertise in medicinal chemistry, chemical biology, photophysics, and neuropharmacology, preparing her for an independent career in translational biomedical research. The role involves performing organic synthesis of novel FSHR inhibitors identified through AI-driven drug discovery, conducting structural and photophysical characterization of these compounds, developing and validating bimodal luminescent–MRI theranostic agents conjugated to FSHR inhibitors, assessing in vitro receptor binding, neuronal uptake, and signaling inhibition in relevant cellular models, and collaborating with the in vivo research team to evaluate the preclinical efficacy of lead compounds in murine models of Alzheimer’s disease.

Requirements

• PhD completion in relevant subject matter.

Responsibilities

• Performing organic synthesis of novel FSHR inhibitors identified through AI-driven drug discovery.
• Conducting structural and photophysical characterization of these compounds using NMR, HPLC, HRMS, fluorescence spectroscopy, and MRI relaxivity assays.
• Developing and validating bimodal luminescent–MRI theranostic agents conjugated to FSHR inhibitors.
• Assessing in vitro receptor binding, neuronal uptake, and signaling inhibition in relevant cellular models.
• Collaborating with the in vivo research team to evaluate the preclinical efficacy of lead compounds in murine models of Alzheimer’s disease, including blood–brain barrier permeability, receptor engagement, and cognitive outcomes.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree