Post-Doctoral Fellow, High-Throughput Functional Genomics

Biohub • Chicago, IL

23h • Onsite

About The Position

Biohub Chicago seeks outstanding early-career experimental scientists with expertise in high-throughput profiling and quantitative biology to join as a Postdoctoral Research Scholar working on single-cell genomics problems in the inflammation space. We welcome candidates from diverse experimental backgrounds—whether rooted in sequencing, imaging, bioengineering, or other modalities—who bring rigorous quantitative thinking and a drive to tackle complex biological questions. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, bioengineering, and disease-focused discovery. Postdoctoral Research Scholars will be embedded in interdisciplinary teams applying and developing high-throughput single-cell genomics approaches to understand inflammatory disease mechanisms. The successful candidate will design and execute quantitative experiments—using sequencing, imaging, bioengineering, or complementary profiling technologies—to dissect cellular heterogeneity, immune cell states, and tissue-level responses in complex biological systems. This role emphasizes both experimental rigor and computational fluency in the analysis of large-scale, high-dimensional datasets. This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.

Requirements

• PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
• Hands-on experience with core wet-lab molecular and cellular biology techniques, as well as high-throughput profiling methods.
• Demonstrated experience in quantitative molecular and cellular biology techniques and high-throughput profiling approaches.
• Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
• Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
• Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.

Nice To Haves

• Experience with high-throughput profiling platforms (e.g., single-cell RNA-seq, spatial transcriptomics, multiplexed imaging, flow/mass cytometry, or proteomics)
• Experience working with primary human cells.
• Experience with technology or assay development, molecular barcoding, novel nucleic acid technologies, or quantitative imaging methods.
• Background in immunology, inflammation biology, or related disease areas.

Responsibilities

• Design and execute quantitative, high-throughput experiments linking perturbations to the function of immune and inflammatory systems.
• Develop, optimize, and apply perturbation readout workflows—including sequencing-based, imaging-based, or multimodal approaches—with rigorous method development, benchmarking, and quality control.
• Collaborate closely with interdisciplinary teams spanning immunology, genomics, computation, and bioengineering to address open questions in inflammation biology.
• Analyze and interpret large-scale, high-dimensional datasets using computational and statistical approaches, and communicate results clearly through figures, presentations, and internal discussions.
• Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.

Benefits

• Generous employer match on employee 401(k) contributions
• Paid time off to volunteer
• Funding for select family-forming benefits
• Relocation support

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree