Post-Doctoral Research Fellow: Functional Genomics & CRISPR

Fred Hutchinson Cancer Center • Seattle, WA

8d • Onsite

About The Position

Fred Hutchinson Cancer Center is seeking a highly motivated and collaborative Post-Doctoral Research Fellow to join the Li Lab, which focuses on cutting-edge CRISPR screening and immuno-oncology. The lab is dedicated to advancing cancer research and developing new treatments by dissecting the molecular and cellular mechanisms driving prostate cancer progression and therapy resistance. They integrate CRISPR-based functional genomics, epigenetic profiling, and chemical biology approaches to identify and characterize novel therapeutic targets, including regulators of androgen receptor (AR) signaling. The lab employs large-scale CRISPR screening, next-generation sequencing, DNA methylation and hydroxymethylation profiling, and in vivo mouse models. The research emphasizes combining genetic, epigenetic, and small molecule perturbations to uncover actionable vulnerabilities in aggressive prostate cancer. The Post-Doctoral Fellow will have opportunities for collaboration and co-mentorship within the Prostate Cancer Program and will lead independent research projects with direct translational relevance to cancer treatment. The successful candidate will have the chance to lead and be first author on projects aimed at identifying novel therapeutic targets and developing new combination treatment strategies.

Requirements

• PhD (or equivalent) in cancer biology, cell biology, genetics, or a related field.
• Strong foundation in molecular biology and cell biology.
• Strong written and oral communication skills.
• Self-motivated, collaborative, and enthusiastic about cancer research.
• Ability to work independently and as part of a team.

Nice To Haves

• Experience with CRISPR-based technologies (screening, base editing, or prime editing).
• Background in cell signaling, gene regulation, or epigenetics.
• Experience with next-generation sequencing and analysis of genomic/epigenomic data.
• Familiarity with DNA methylation biology, including 5mC and 5hmC regulation.
• Interest in designing genome-wide or custom CRISPR screening libraries.
• Experience with single-cell sequencing approaches.
• Interest or experience in chemical biology, small-molecule screening, or degrader design.
• Comfort working across in vitro systems and in vivo mouse models.

Responsibilities

• Design and execute independent research projects under the mentorship of Dr. Li.
• Develop and implement high-throughput CRISPR-based screening strategies.
• Integrate genetic, epigenetic, and pharmacologic perturbations to study cancer biology.
• Apply for independent funding (intramural and extramural).
• Participate in grant writing, manuscript preparation, lab meetings, and journal clubs.
• Mentor junior lab members, including technicians and students.
• Contribute to and lead publications in high-impact journals.

Benefits

• Medical/vision
• Dental
• Flexible spending accounts
• Life insurance
• Disability insurance
• Retirement plan
• Family life support
• Employee assistance program
• Onsite health clinic
• Income-based child care subsidy
• Tuition reimbursement
• Paid vacation (22 days per year)
• Paid sick leave (up to 30 calendar days per occurrence of a qualifying reason)
• Paid holidays (13 days per year)
• Paid parental leave (up to 4 weeks)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 501-1,000 employees