Portfolio & Program Manager

GSK•Marietta, PA

12d

About The Position

GSK is making an $800M+ investment in a state-of-the-art manufacturing facility that will strengthen future supply, advance pharmaceutical innovation, and help set a new benchmark for operational excellence. This is a rare opportunity to work on $650MM+ capital project from the ground up and contribute to a transformative program with strategic importance for GSK and the patients we serve. The Portfolio & Program Manager will provide program-level leadership for end-to-end readiness planning and execution for new facility introduction. This role will integrate complex cross-functional workstreams into a single, executable readiness plan; drive governance discipline; identify acceleration opportunities; and establish the GPS, digital, and operating system foundations required for operational excellence from day one. Working in close partnership with construction, commissioning, quality, supply, procurement, technology transfer, automation/digital, and operations leaders, the role will ensure the site is prepared for handover, PPQ, and facility approval through disciplined execution of SOPs, training, tech transfer alignment, incoming materials readiness, procurement delivery, and proactive risk management. This role is designed for a leader who can bring clarity, pace, and accountability to a complex manufacturing start-up environment. The successful candidate will influence 9 different workstreams and cross functions, translate strategic priorities into executable plans, and enable a safe, compliant, and sustainable transition from project delivery to operational performance.

Requirements

BS/BA in Engineering, Business, Life Sciences, Operations, Supply Chain, or a related field; MS or MBA preferred for senior-level scope.
6+ years of experience in project, portfolio, or program management, ideally within manufacturing, operations, supply, quality, or regulated technical environments.
3+ years of experience in effective planning, managing and tracking projects and portfolio in Microsoft Projects, Power-BI Dashboards and other PMO software.

Nice To Haves

Experience of working in pharmaceutical companies.
New facility introduction, expansion, or capital project experience, with operational readiness executed in parallel with construction and commissioning.
Demonstrated program or portfolio management experience, including integrated schedules, dependency management, critical path governance, and leadership reporting.
Experience leading cross-functional readiness, launch, or operationalization programs in regulated manufacturing environments.
Strong risk and issue management discipline, including risk registers, mitigation ownership, escalation, and decision tracking.
Executive-ready communication skills, including concise dashboards, narrative updates, decision framing, and clear escalation messaging.
Familiarity with tier-based management systems, shopfloor governance, GPS, and performance management cadence.
Lean or Six Sigma experience, particularly where continuous improvement, deployment, or standard work is expected.
Exposure to digital manufacturing readiness, including MES/eBR coordination, master data, automation, analytics, or related digital foundations.

Responsibilities

Develop, maintain, and govern the integrated operational readiness master schedule across SOPs, technology transfer, GPS, incoming materials, procurement, digital readiness, and related workstreams, ensuring alignment with the Integrated Master Schedule and critical path.
Drive schedule convergence and acceleration by identifying dependencies, sequencing conflicts, resource constraints, and pull-forward opportunities; lead weekly lookahead planning and escalation of overdue or at-risk deliverables.
Establish readiness stage-gates, define entry and exit criteria, and align stakeholders on evidence-based readiness decisions at critical program milestones.
Lead prioritization, drafting, field shakedown, review, and approval planning for SOPs and supporting documents required to enable shopfloor readiness.
Define clear document strategy and ownership across SOPs, eBR/MES content, and local instructions; maintain an integrated document tracker aligned to the master schedule.
Oversee closure of safety, HAZOP, and risk assessment actions, ensuring accountable owners, timely completion, and appropriate escalation where required.
Coordinate across functions to ensure outstanding safety, compliance, and risk-related actions are resolved and communicated effectively.
Ensure operational readiness deliverables remain aligned with technology transfer plans, donor site inputs, QC method transfer planning, and facility approval requirements.
Integrate key technology transfer and QC readiness milestones into site governance, leadership reporting, and decision forums.
Provide oversight of change control readiness to ensure regulatory alignment, efficient execution, and delivery against established timelines.
Continuously improve change management practices by reinforcing ownership, decision quality, and timely execution in support of program objectives.
Coordinate supplier transparency, material master data readiness, BOM redlines, and incoming materials strategy to support commissioning, start-up, and PPQ readiness.
Ensure materials readiness is integrated with eBR/MES requirements, procurement lead times, and facility start-up sequencing.
Track procurement readiness for critical packages, identify readiness blockers, and coordinate mitigation where procurement timing may affect the critical path.
Partner with engineering and project teams to ensure procurement deliverables support FAT/SAT, commissioning, start-up, and operational readiness requirements.
Integrate smart manufacturing and digital readiness activities across workstreams to improve process visibility, data-driven decision-making, automation readiness, and operational control.
Collaborate with IT, engineering, automation, and operations partners to deploy advanced manufacturing systems, including MES/eBR, real-time analytics, IoT-enabled capability, and digital twin foundations where applicable.
Lead the operational readiness risk and issue management rhythm, including identification, assessment, mitigation planning, ownership, and escalation.
Maintain and govern the project risk register, ensuring mitigations have clear owners, due dates, escalation paths, and schedule integration.
Facilitate recurring risk reviews and ensure lessons learned are translated into stronger schedules, training plans, controls, and readiness deliverables.
Manage and track all handover process and documentation from global capital team.
Develop and maintain readiness dashboards, tier boards, and scorecards covering safety, quality, supply, schedule conformance, and critical path performance.
Define and implement KPI reporting discipline for weekly governance and monthly leadership updates, ensuring data integrity and clear linkage to decisions and actions.
Track readiness KPIs such as right-first-time execution, schedule adherence, critical path health, and risk mitigation progress; drive countermeasures through tier governance.