Portfolio Operations Manager

Roche•South San Francisco, CA
•$142,200 - $264,200•Remote

About The Position

The Portfolio Operations Manager owns the operating system that enables CE to evaluate, prioritize, sequence, and govern enterprise work as one portfolio. The role manages intake of proposed work, the prioritized CE portfolio roadmap, governance and decision cadence, and an integrated view of dependencies, duplication, capacity, and tradeoffs. The manager partners with CE Leadership, Enterprise Operations, Regions, HEDs, RBO teams, and other stakeholders to direct resources toward the highest-priority work and support transparent decisions when priorities compete. The position maintains an integrated portfolio covering initiatives, launches, RBO work, and field-partner commitments; translates CE strategy into a prioritized roadmap; and provides visibility into timing, sequencing, interdependencies, milestones, risks, and capacity. It owns intake and evaluation processes, facilitates prioritization and governance discussions, prepares decision materials, and develops capacity, sequencing, and tradeoff recommendations. The manager also leads and develops Enterprise Operations Leads assigned to portfolio and RBO work, establishes portfolio standards, and builds portfolio management capabilities across the team. The role requires a bachelor's degree and 8–10 years of relevant experience in areas such as pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, or operations. Experience leading, coaching, or mentoring others is strongly preferred. The role may be based in SSF or remote; relocation benefits are not available. Travel may be required for internal and external business meetings.

Requirements

  • Bachelor's degree required.
  • 8–10 years of pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, and/or operations experience; leading, coaching, or mentoring others is strongly preferred.
  • Demonstrated experience with portfolio management, prioritization, governance, or resource planning.
  • Experience facilitating senior leadership decisions involving competing priorities and tradeoffs.
  • Strong analytical, synthesis, and project/program management capabilities.
  • Demonstrated ability to influence across a complex matrixed organization.
  • Strong communication and executive presentation skills.
  • Ability and willingness to travel as required for internal and external business meetings.

Nice To Haves

  • Graduate-level degree, such as an MBA or advanced life sciences degree.
  • Prior commercial operations, portfolio management, strategy, or transformation experience.
  • Experience supporting large-scale field organizations, RBO, or enterprise planning processes.
  • Experience leading, coaching, or mentoring others.

Responsibilities

  • Maintain the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments.
  • Translate CE strategy and leadership priorities into a prioritized portfolio roadmap, with visibility into timing, sequencing, interdependencies, and milestones.
  • Identify duplication, overlap, and opportunities to combine or simplify portfolio work.
  • Own intake and evaluation of proposed enterprise work and establish criteria for alignment, impact, urgency, effort, capacity, and enterprise value.
  • Facilitate prioritization discussions and develop recommendations when demand exceeds available capacity.
  • Ensure proposed work has a sponsor, problem statement, intended outcome, and required decision before entering the portfolio.
  • Route approved work to the appropriate Enterprise Operations manager, lead, or enabling team for execution.
  • Manage portfolio governance cadence and prepare decision materials for CE Leadership and CELT as needed.
  • Maintain decision logs and escalation paths, and follow through on portfolio choices.
  • Synthesize portfolio changes, their significance, and required decisions or tradeoffs; focus governance on material decisions, risks, and dependencies.
  • Partner with initiative and launch teams to maintain accurate portfolio status and milestone visibility.
  • Maintain an integrated view of enterprise capacity, demand, dependencies, and resource constraints; develop capacity, sequencing, and tradeoff recommendations.
  • Integrate RBO work into the broader CE portfolio and surface cross-portfolio risks and constraints early.
  • Partner with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate shared resources.
  • Lead, coach, and develop Enterprise Operations Leads assigned to portfolio and RBO work.
  • Set standards for portfolio data quality, governance materials, decision support, and milestone tracking.
  • Allocate team capacity to the highest-priority portfolio needs and time-sensitive decisions.
  • Build portfolio management capabilities, tools, and ways of working across the team, and contribute to Enterprise Operations standards, talent practices, and continuous improvement.

Benefits

  • A discretionary annual bonus may be available based on individual and Company performance.
  • The position qualifies for company benefits detailed at the linked benefits page; specific benefits are not listed in the description.
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