Portfolio Operations Manager

Genentech • Los Angeles, CA

3d • $142,200 - $264,200

About The Position

The Portfolio Operations Manager owns the operating system that enables CE to evaluate, prioritize, sequence, and govern enterprise work as a unified portfolio. The role manages intake of proposed enterprise work, the prioritized CE portfolio roadmap, governance and decision cadence, and an integrated view of dependencies, duplication, capacity, and tradeoffs. The manager partners with CE Leadership, Enterprise Operations, Regions, HEDs, RBO teams, and other stakeholders to focus resources on high-priority work and support transparent decisions when priorities compete.

The role maintains the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments; translates strategy and leadership priorities into a roadmap; and makes portfolio timing, sequencing, interdependencies, and milestones visible. It owns the intake and evaluation process, establishes prioritization criteria, facilitates discussions, and recommends actions when demand exceeds capacity. It also manages governance cadence and decision materials, tracks portfolio choices, and synthesizes changes, risks, dependencies, decisions, and tradeoffs for leadership.

The manager maintains an integrated view of capacity, demand, dependencies, and resource constraints, integrates RBO commitments into the broader portfolio, and partners with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate resources. The position leads, coaches, and develops Enterprise Operations Leads assigned to portfolio and RBO work; sets standards for portfolio data, governance materials, decision support, and milestone tracking; and builds portfolio management capabilities and ways of working across the team.

The position can be based in SSF or remotely. Relocation benefits are not available. The expected annual salary range for the primary location of California is $142,200–$264,200. Actual pay depends on experience, qualifications, geographic location, and other job-related factors. A discretionary annual bonus may be available based on individual and Company performance. The position qualifies for benefits detailed at a linked benefits page.

Requirements

• Bachelor's degree required.
• 8–10 years of pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, and/or operations experience; leading, coaching, or mentoring others is strongly preferred.
• Demonstrated experience with portfolio management, prioritization, governance, or resource planning.
• Experience facilitating senior leadership decisions involving competing priorities and tradeoffs.
• Strong analytical, synthesis, and project/program management capabilities.
• Demonstrated ability to influence across a complex matrixed organization.
• Strong communication and executive presentation skills.
• Ability and willingness to travel as required for internal and external business meetings.

Nice To Haves

• Graduate-level degree, such as an MBA or advanced life sciences degree.
• Prior commercial operations, portfolio management, strategy, or transformation experience.
• Experience supporting large-scale field organizations, RBO, or enterprise planning processes.
• Experience leading, coaching, or mentoring others is strongly preferred.

Responsibilities

• Maintain the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments.
• Translate CE strategy and leadership priorities into a prioritized portfolio roadmap.
• Provide visibility into portfolio timing, sequencing, interdependencies, and major milestones.
• Identify duplication, overlap, and opportunities to combine or simplify work.
• Keep portfolio views current, decision-oriented, and useful to CE Leadership and operating teams.
• Own the intake and evaluation process for proposed enterprise work.
• Establish criteria for strategic alignment, impact, urgency, effort, capacity, and enterprise value.
• Facilitate prioritization discussions and develop recommendations when demand exceeds available capacity.
• Ensure proposed work has a clear sponsor, problem statement, intended outcome, and required decision before entering the portfolio.
• Route approved work to the appropriate Enterprise Operations manager, lead, or enabling team for execution.
• Manage portfolio governance cadence and prepare decision materials for CE Leadership and CELT as needed.
• Maintain transparent decision logs and escalation paths, and follow through on portfolio choices.
• Synthesize what is changing, why it matters, and what decisions or tradeoffs are required.
• Keep governance focused on material decisions, risks, and dependencies rather than routine status reporting.
• Partner with initiative and launch teams to maintain accurate portfolio status and milestone visibility.
• Maintain an integrated view of enterprise capacity, demand, major dependencies, and resource constraints.
• Develop capacity, sequencing, and tradeoff recommendations across competing priorities.
• Integrate RBO work into the broader CE portfolio so Regional and HED-supported commitments are visible and prioritized.
• Surface cross-portfolio risks and constraints early enough to enable leadership action.
• Partner with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate shared resources.
• Lead, coach, and develop Enterprise Operations Leads assigned to portfolio and RBO work.
• Set standards for portfolio data quality, governance materials, decision support, and milestone tracking.
• Allocate team capacity to the highest-priority portfolio needs and time-sensitive decisions.
• Build portfolio management capabilities, tools, and ways of working across the team.
• Contribute to common Enterprise Operations standards, talent practices, and continuous improvement.
• Travel as required for internal and external business meetings.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• The position qualifies for company benefits detailed at the linked benefits page.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager