Pharmacology Research Scientist, Ex Vivo

Vertex Inc.•Boston, MA

1d•$110,900 - $166,300•Onsite

About The Position

The CGT Pharmacology group in Boston is seeking a highly motivated and innovative Pharmacology Research Scientist to work collaboratively across the Research organization by supporting pharmacology efforts to understand the pharmacokinetics, pharmacodynamics, and efficacy of novel cell and gene therapies in disease models. The successful candidate will focus on developing, optimizing and validating PK/PD assays, immunoassays, custom multiplexes, and primary cell/explant assays supporting both early discovery and IND-enabling phases. This role requires a specialized technical expert in assay development (e.g. immunoassays, cell assays, flow assays, etc.) who can lead work streams, prioritize data integrity/documentation and mentor others within the team. Strong technical and problem-solving skills, self-motivation, presentation/communication skills, and the ability to both leads, as well as thrive as part of a team are essential.

Requirements

Proven technical proﬁciency and demonstrated skill in planning and interpreting experiments, including the measurement of the action of cell/gene therapies on in vitro or in vivo disease biology assays (PK/PD, Ligand Binding assays, primary cell/tissue culture, immune cell assays, custom multiplex, flow cytometry).
Strong analytical and organizations skills with the ability to operate automated assay systems and analyze/collect data to interpret complex data sets (Hamilton, Integra, etc.)
Proficiency in data analysis software and tools (GraphPad Prism, Spotfire, FlowJo, VENUS lab automation software, etc.).
Assesses situations using existing knowledge and best practices, proactively asking for assistance when defined boundaries or technical limitations are reached.
Demonstrates understanding of analysis and interpretation of relatively complex experimental data with proﬁciency in problem solving and protocol/procedure reﬁnement.
Effective communicator (written and verbal) and presenter, with the ability to work effectively in a collaborative team environment.
Bachelor’s degree and 10 years of industry experience or, Master’s degree and 5 years of industry experience or, PhD and 3 years of industry experience

Nice To Haves

Specialized technical expert in assay development (e.g. immunoassays, cell assays, flow assays, etc.) who can lead work streams, prioritize data integrity/documentation and mentor others within the team.
Strong technical and problem-solving skills, self-motivation, presentation/communication skills, and the ability to both leads, as well as thrive as part of a team are essential.

Responsibilities

Designs, optimizes and executes preclinical PK, and immunoassay and cell assays to support pharmacology research efforts
Uses a high level of scientific judgment and creative thinking to adapt and/or create standardized workflows & protocols by applying breadth of knowledge and prior work experience.
Takes ownership of daily tasks, researching answers and contacting other subject matter experts independently before soliciting support from senior team members.
Exercises emerging judgment to prioritize workload, based on project impact.
Communicate and work collaboratively within and across functions to support programs from early discovery through preclinical proof of concept and candidate selection to advance the company pipeline.
Authors and reviews Bioanalytical reports for regulatory filings
Analyze, interpret, and present experimental data to project teams and senior leadership.
Possesses a strong understanding of the drug development process and showcases enterprise thinking.