Associate Scientist, In Vivo Pharmacology

Parvus Therapeutics • South San Francisco, CA

2d • Onsite

About The Position

Parvus Therapeutics Inc. is a privately held biopharmaceutical company developing Navacims™, a platform technology based on foundational research published in 2016 (Nature 530:434), to treat autoimmune diseases. Parvus’ mission is to shift the treatment paradigm toward Navacim™-directed immune regulation, avoiding non-specific immune suppression associated with current therapies. Parvus’ innovative approach has the potential to benefit millions of patients suffering from debilitating autoimmune diseases and other chronic inflammatory conditions. Parvus is advancing a pipeline of proprietary drug candidates for multiple autoimmune indications through preclinical development and into the clinic. Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization.

We are seeking an Associate Scientist to help drive projects enabling the preclinical PK/PD characterization of pMHC NP towards clinical and combination therapy evaluation. This role will also establish model development to foster our clinical pipeline growth and life cycle management.

Requirements

• Bachelors degree with a minimum of 8 years of experience or Masters degree with a minimum of 6 years of experience in Immunology or other relevant life sciences (2 years must be in biotech or industry setting).
• Familiarity with animal handling, survival blood draws (lateral tail vein, facial/maxilliary/submandibular), terminal blood draws (cardiac puncture), and dosing methods including i.v., s.c., i.p., and p.o. a must.
• Independently execute immune models in relevant rodent species including but not limited to type 1 diabetes, colitis, lupus, rheumatoid arthritis, and multiple sclerosis.
• Experience running GSP/”GLP-like” studies suitable for regulatory submissions including gross necropsy and tissue preparations for histopathology.

Nice To Haves

• Knowledge of surgical techniques including transplantation and portal vein infusion
• Experience with common bioanalytical methods such as Ligand binding assays, flow cytometry
• Experience writing study reports
• Excellent oral, written communication, and presentation skills.
• Demonstrated ability to effectively work in cross-functional teams, meet deadlines, and prioritize multiple projects is required.
• Comfortable working collaboratively in a small, fast-paced environment.
• Ability to quickly adjust to shifting project demands and priorities.

Responsibilities

• Lead in vivo PK/PD model development or execution including biospecimen collection, processing, and analyses.
• Serve as study monitor or study lead for IND-enabling studies performed in-house.
• Write and amend IACUC protocols and internal SOPs as necessary.
• Liaise with vivarium staff as necessary.
• Oversee animal vendors, CROs, and diagnostic labs to ensure timely completion of non-GLP in vivo studies.
• Participate in all aspects of vivarium and lab operation, training, and compliance including external audits where applicable.
• Other duties and responsibilities as assigned.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level