Molecular Biology Research Associate

Cynet Systems•Framingham, MA
•Onsite

About The Position

The candidate in this role will work as part of the Cell Line Development (CLD) Group, joining a team responsible for generating, storing, and distributing DNA plasmids to support pipeline and technology development within CLD. As a member of the core molecular biology team, the successful candidate will provide recombinant DNA plasmids essential to cell line generation, combining strong molecular biology skills with the ability to understand and execute complex cloning strategies. Beyond producing plasmids requested de novo, the candidate will also support plasmid and data management activities across the group. Day-to-day responsibilities include retrieving stored DNA plasmids, managing DNA upscaling both in-house and at contract research organizations (CROs), performing quality control on newly generated DNA batches, and delivering finished materials to requestors. The role also involves processing new DNA batches and entering associated metadata into the repository and freezer tracking system. The candidate brings strong molecular biology expertise along with the ability to troubleshoot and resolve problems using sound initiative and judgment. Success in this role requires the ability to thrive in a fast-paced environment while maintaining a high level of attention to detail, strong organizational and data presentation skills, and the ability to work collaboratively—communicating effectively both within the immediate team and across broader groups.

Requirements

  • Molecular biology skills including GoldenGate, InFusion, and Gibson Assembly cloning technologies
  • Knowledge in plasmid construct design (including antibodies)
  • Agarose gel electrophoresis
  • DNA purification
  • DNA sequencing
  • Sequence analysis
  • Knowledge of molecular biology software such as Snapgene or Geneious
  • Excellent oral and written communication skills
  • BS or MS in biology or a related field
  • 1+ years of experience in a research laboratory or a biopharma/biotech company

Nice To Haves

  • Experience with automation
  • Experience with LIMS (Laboratory Information Management System)
  • Experience with biological registration systems (example: Genedata Biologics)

Responsibilities

  • Generating, storing, and distributing DNA plasmids
  • Providing recombinant DNA plasmids essential to cell line generation
  • Understanding and executing complex cloning strategies
  • Supporting plasmid and data management activities
  • Retrieving stored DNA plasmids
  • Managing DNA upscaling both in-house and at contract research organizations (CROs)
  • Performing quality control on newly generated DNA batches
  • Delivering finished materials to requestors
  • Processing new DNA batches
  • Entering associated metadata into the repository and freezer tracking system
  • Troubleshooting and resolving problems using sound initiative and judgment
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