Medicinal Chemist (R5 – R7)
About The Position
Eli Lilly and Company seeks a Medicinal Chemist (R5-R7) to formulate hypotheses, and design and synthesize novel small molecules. Optimize lead compounds to improve potency, selectivity, physicochemical properties, and ADMET to meet the target product profiles required to invent high-quality medicines. Collaborate with external CRO chemistry resources to implement design ideas and optimize chemistry productivity. Direct fast-paced SAR iterations through proposal and execution of synthetic routines. Maintain a strong safety culture. Partner cross-functionality to address specific program needs, increase overall organization, and provide Medicinal Chemistry perspectives.
Requirements
- Master’s degree in Chemistry, Medicinal Chemistry, Biochemistry, or a related chemistry discipline, and 4 years of academic or employment experience with synthetic organic chemistry or medicinal chemistry.
- OR PhD in Chemistry, Medicinal Chemistry, Biochemistry, or a related chemistry discipline, and 1 year of academic or employment experience with synthetic organic chemistry or medicinal chemistry.
- Minimum of 1 year of experience supporting drug discovery at the molecular design stage.
- Minimum of 1 year of experience with improving in vitro and in vivo potency, selectivity, and ADMET properties.
- Minimum of 1 year of experience with new modalities including targeted protein degradations, siRNA, ADCs, and oral peptides.
- Up to 10% domestic and/or international travel required.
Responsibilities
- Formulate hypotheses, and design and synthesize novel small molecules.
- Optimize lead compounds to improve potency, selectivity, physicochemical properties, and ADMET to meet the target product profiles required to invent high-quality medicines.
- Collaborate with external CRO chemistry resources to implement design ideas and optimize chemistry productivity.
- Direct fast-paced SAR iterations through proposal and execution of synthetic routines.
- Maintain a strong safety culture.
- Partner cross-functionality to address specific program needs, increase overall organization, and provide Medicinal Chemistry perspectives.
Benefits
- company bonus (depending, in part, on company and individual performance)
- company-sponsored 401(k)
- pension
- vacation benefits
- eligibility for medical, dental, vision and prescription drug benefits
- flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
- life insurance and death benefits
- certain time off and leave of absence benefits
- well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
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What This Job Offers
Job Type
Full-time
Career Level
Senior
