Medicinal Chemist

Inductive Bio

About The Position

Inductive Bio is an AI medicinal chemistry partner that builds virtual labs to help drug discovery teams make better decisions, faster, across the full DMTA cycle. Their platform includes Beacon-1 ADMET prediction models, human dose projection tools, and Indy, an AI medicinal chemistry assistant. Through partnerships with CROs, they offer innovative synthesis approaches, direct-to-dose testing, and cost-effective tier 1 ADME panels that enable initial human PK projection, closing the loop from computational design to experimental validation. Inductive Bio has raised $30M from Obvious Ventures, a16z Bio + Health, and Lux Capital, and was selected for a $21M ARPA-H CATALYST award to develop next-generation toxicity models. They are seeking an accomplished Medicinal Chemist to play a key role in building an AI-forward drug discovery platform that impacts all stages of the Design-Make-Test-Analyze cycle, and deploy that platform to dozens of programs across the industry.

Requirements

An ideal candidate is a creative and accomplished medicinal chemist with a synthetic organic chemistry background who has played a meaningful role in advancing compounds to the development candidate stage.
You have direct experience at all stages of drug discovery projects, and can point to go/no go judgement calls you’ve made in lead generation and lead optimization.
You’ve used different approaches to evaluate compound quality, from LLE to dose prediction, and appreciate the importance of contextualizing results in terms of their expected profile in humans.
The more modalities you’ve worked with, the better, from reversible and covalent to heterobifunctionals and peptides.
Along with designing compounds and analyzing data, you have years of experience in chemical synthesis with CROs. As you think about synthetic strategy, you look for convergent routes and late-stage intermediates.
You communicate effectively and proactively, seek feedback, handle proprietary information with discretion, embrace transparency, and treat others with respect.

Nice To Haves

Experience with predictive models and automation is a plus! (e.g. FEP, predictive ADME, AI retrosynthesis, direct to biology)

Responsibilities

Be an embedded expert, supporting a variety of partner drug discovery programs from lead generation through development candidate nomination across diverse small molecule modalities.
Alongside outstanding compchem, DMPK, and machine learning colleagues, bring Inductive’s tools and your medchem knowledge to our work as consultants on partners’ projects.
Help deliver value to partners through Inductive’s experimental offerings, where we combine our drug discovery experience, predictive models, and AI workflows with our chemistry and assay CRO partners to answer hypotheses effectively.
Build an AI-native drug discovery platform that will speed drugs to the clinic. Help make your ideas about how to improve the DMTA cycle a reality, as we flesh out Indy (our AI medicinal chemistry agent) and build assay and synthesis workflows that get to high-quality answers more quickly.
Represent Inductive’s mission and build connections in the field, meeting with current and potential partners, gathering feedback about what drug discovery teams need, attending conferences and meetings, giving presentations, and authoring blog posts and publications.