Medical Director

Sutro Biopharma•South San Francisco, CA

7d•Onsite

About The Position

Sutro Biopharma, Inc. is seeking a driven and talented individual to join our Clinical Development team as we change the future of oncology. While collaborating with cross-functional departments, you will play a key leadership role in advancing our next-generation antibody-drug conjugate (ADC) portfolio. This individual will provide medical leadership across early clinical development programs, with a strong focus on Phase 1 and Phase 2 studies. The Medical Director role is ideally suited for a physician-scientist with deep oncology expertise and prior experience in ADCs or targeted therapies. However, outstanding individuals with strong growth potential at an earlier stage of their career will also be considered. The appointee will work cross-functionally to translate Sutro’s differentiated, cell-free ADC platform, including single- and dual-payload technologies, into innovative clinical strategies aimed at improving efficacy, overcoming resistance, and expanding treatment options for patients with cancer. This position is an opportunity to be involved in translating industry-leading research and development from the laboratory into the clinic.

Requirements

MD or MD/PhD required
Board certification or eligibility in Oncology or Hematology/Oncology preferred
Minimum of 2-5+ years of relevant experience with a minimum of 2 years of oncology clinical trial experience in pharmaceutical or biotech industries preferred
Demonstrated experience leading or contributing to early-phase (Phase 1 and/or Phase 2) oncology clinical trials
Prior experience with antibody-drug conjugates (ADCs) strongly preferred; experience with targeted therapies or biologics is a plus
Solid understanding of oncology drug development, including clinical endpoints, dose escalation strategies, safety monitoring, and regulatory requirements
Experience serving as a medical monitor on a registration study and interacting with regulatory agencies (e.g., FDA)
Knowledgeable and current in GCP guidelines in US and Europe
Strong scientific, analytical, and strategic thinking skills, with the ability to interpret complex clinical and translational data
Proven ability to work effectively in a cross-functional, fast-paced biotech environment

Nice To Haves

Experience with novel payloads, linker technologies, or platform-based drug development approaches
Familiarity with resistance mechanisms and combination strategies in oncology
Clinical practice experience or experience as an investigator is a plus.
Background in translational medicine and biomarker-driven development
Track record of scientific publications and external presentations
Ability to operate with agility and influence in a small, collaborative organization
Excellent leadership, strategic thinking, and communication skills.
Demonstrated commitment to high personal values and ethical standards.

Responsibilities

Provide medical leadership for the design, execution, and interpretation of Phase 1/2 oncology clinical trials, with a focus on ADC programs
Serve as medical monitor for assigned studies, ensuring patient safety, protocol compliance, and high-quality data
Lead development of clinical protocols, investigator brochures, clinical study reports, and other key regulatory documents
Contribute to and help shape overall clinical development strategy for ADC assets, including first-in-human studies and expansion cohorts
Partner closely with translational sciences to integrate biomarker strategies, PK/PD insights, and mechanism-of-action data into clinical development plans
Collaborate cross-functionally with clinical operations, regulatory affairs, CMC, nonclinical, and biometrics teams to ensure seamless program execution
Engage and build strong relationships with key opinion leaders, investigators, and academic collaborators in oncology
Support regulatory strategy and interactions, including preparation for FDA and global health authority meetings
Analyze and interpret emerging clinical and translational data to inform dose selection, safety management, and program decisions
Contribute to scientific publications, conference presentations, and external communications