Medical Director, US Medical Affairs, HCM

Cytokinetics•Radnor, PA

4d•Hybrid

About The Position

The Medical Director, US Medical Affairs, Hypertrophic Cardiomyopathy (HCM) is a key member of Cytokinetics’ Medical Affairs team. This role collaborates across Medical Affairs and with Commercial and Clinical departments to develop and execute the Medical Affairs plan for aficamten and support strategic planning and lifecycle management across the cardiovascular portfolio. As a cardiology and HCM subject matter expert, the Medical Director provides internal scientific and medical guidance, resolves medical issues, and contributes to medical documents and materials to ensure high strategic and scientific standards. The role may represent Medical Affairs externally at advisory boards and scientific meetings and through interactions with investigators, and supports partnerships with key opinion leaders, academic institutions, and professional societies. The Medical Director supports aficamten development, launch readiness, and lifecycle management; contributes to medical strategy, evidence generation, education, scientific communications, and cross-functional initiatives; and collaborates with US Field Medical Affairs and regional and global colleagues. The position also supports medical review of scientific and promotional materials, healthcare professional inquiries, field medical training, and engagement with HCM experts. The role is based primarily in South San Francisco, California, and requires approximately 30% travel.

Requirements

MD/DO or PharmD degree.
Three to five years of Medical Affairs experience, with prior pharmaceutical industry and Medical Affairs Medical Director experience required.
Ability to critically evaluate and interpret clinical trial data, peer-reviewed literature, treatment guidelines, and real-world evidence.
Ability to work independently and as part of an integrated, interdisciplinary team.
Ability to translate complex scientific information into clear, accurate, actionable medical guidance.
Strong project-management skills, including management of multiple priorities, budgets, vendors, timelines, and deliverables.
Analytical and articulate oral and written communication skills, excellent presentation and executive communication skills, and ability to communicate effectively with people at varying professional levels.
High scientific integrity, sound medical judgment, professionalism, and commitment to patient benefit.
Proficiency with Microsoft Office.
Ability to travel approximately 30% of the time.

Nice To Haves

Cardiovascular training and clinical experience strongly preferred.
Demonstrated knowledge of Medical Affairs strategy, including evidence generation, scientific communications, and external engagement strongly preferred.
Experience with product approvals, launch, and peri-launch activities highly desirable.
Background in academic medicine and clinical research, and familiarity with biostatistics and epidemiology, highly desirable.
Experience managing vendors, budgets, and strategic timelines is a plus.
Experience developing medical plans and aligning medical objectives with broader product and organizational strategy is a plus.
Familiarity with OPDP, the PhRMA Code, and key pharmaceutical-industry regulations is a plus.
Working knowledge of congress strategy, advisory boards, medical education, and scientific communications.

Responsibilities

Assist in developing and executing medical strategy, including the US Plan of Action, aligned with organizational, therapeutic-area, and product objectives.
Serve as a medical and scientific expert for the assigned therapeutic area and educate healthcare professionals about aficamten’s clinical profile and place in HCM therapy.
Provide medical leadership throughout aficamten development, launch readiness, launch activities, and lifecycle management.
Provide medical input into cross-functional, brand, evidence-generation, market-access, and lifecycle-management plans, including REMS activities.
Partner with Clinical Development, Commercial, Regulatory, Safety, HEOR, Market Access, and Legal/Compliance on strategic workstreams and deliverables.
Collaborate with regional and global colleagues to align strategy while addressing local stakeholder needs.
Participate in cross-functional Medical and Commercial teams to inform aficamten brand strategies and tactics.
Provide input into HCM medical education, grant, and sponsorship review; assess the reach, quality, and impact of medical education initiatives.
Manage medical programs, vendors, timelines, budgets, contracts, and performance measures.
Provide clinical and scientific support in responding to healthcare professional inquiries.
Support Medical Affairs review of medical and promotional scientific materials related to HCM and aficamten through MLR.
Participate in integrated evidence plan development, identify evidence gaps, and contribute to evidence-generation strategy, including real-world evidence and investigator-sponsored research.
Collaborate with Field Medical Affairs to establish scientific priorities, training plans, and insight and stakeholder-engagement strategies; analyze field insights to inform medical, evidence-generation, and educational strategy.
Collaborate with US Field Medical Affairs on field-material development and healthcare professional inquiries, and assist with field education on emerging aficamten data and HCM topics.
Build and maintain an active US HCM key opinion leader expert network, and engage external HCM experts in scientific exchange to meet the needs of patients and the medical community.
Represent Medical Affairs externally, as appropriate, through presentations at advisory boards and scientific meetings and interactions with key investigators.
Contribute to scientific congress strategy and planning, advisory boards, field-force training, medical information response letters, health economics and epidemiology analyses, and marketing- and policy-related projects.