Director, US Medical Affairs, PDAC

Revolution Medicines

2d•$201,000 - $251,000•Remote

About The Position

The Director, US Medical Affairs - PDAC will support the development and execution of the US Medical Affairs strategy and tactical plan for pancreatic ductal adenocarcinoma (PDAC). The role serves as a US medical and scientific partner for cross-functional teams, translating the evolving PDAC treatment landscape, external expert perspectives, and field insights into focused medical priorities and activities. The Director contributes to launch readiness and post-approval medical activities, including scientific engagement, evidence generation, medical communications, internal education, and patient-focused initiatives. The role works closely with US Field Medical, Clinical Development and Operations, Medical Information, Medical Communications, HEOR/RWE, Biomarker and Companion Diagnostics, Commercial, Market Access, Regulatory, Safety, Legal, and Compliance. The ideal candidate is scientifically rigorous, collaborative, proactive, and comfortable in a fast-paced environment, with the ability to synthesize complex evidence, develop clear scientific narratives, and execute medical tactics addressing meaningful needs in PDAC care.

Requirements

Advanced clinical or scientific degree such as PharmD, PhD, MD, DO, or equivalent.
10 or more years of relevant experience in Medical Affairs within biotechnology or the pharmaceutical industry and/or prior clinical oncology practice.
Strong scientific background in oncology, with meaningful experience in gastrointestinal cancers; direct PDAC experience is strongly preferred.
Ability to analyze, synthesize, and communicate complex clinical and scientific information to internal and external audiences.
Hands-on experience across core Medical Affairs activities, such as medical strategy, field medical partnership, medical communications, medical information, evidence generation, publications, congress planning, advisory boards, and internal training.
Experience working effectively with cross-functional partners, including Clinical Development, HEOR/RWE, Biomarkers/Diagnostics, Commercial, Market Access, Regulatory, Safety, Legal, and Compliance.
Excellent written, verbal, and presentation skills, with the ability to communicate a clear scientific point of view while maintaining appropriate medical balance.
Ability to manage multiple priorities and stakeholders in a dynamic, evolving environment.
Ability to travel for internal meetings, external expert engagements, and medical congresses, as required.

Nice To Haves

Established relationships with US PDAC experts, investigators, advocacy organizations, and multidisciplinary care stakeholders.
Experience supporting oncology product launch readiness, launch execution, or post-launch medical strategy in the United States.
Experience in precision oncology, RAS biology, biomarker testing, companion diagnostics, or targeted therapy development.
Understanding of the US PDAC care pathway, including community and academic treatment settings, patient referral patterns, molecular testing, treatment sequencing, and key evidence gaps.
Experience supporting clinical-trial strategy or execution, including protocol review, site and investigator engagement, enrollment support, and interpretation of clinical data.

Responsibilities

Contribute to the development and execution of the US Medical Affairs strategy and annual medical plan for PDAC, including launch readiness, launch execution, and lifecycle planning.
Translate US-specific evidence gaps, treatment patterns, stakeholder needs, and field insights into medical objectives and executable tactics.
Lead or support scientific engagement with US external experts through advisory boards, investigator interactions, congress activities, and peer-to-peer scientific exchange.
Partner with US Field Medical to develop scientific priorities, insight-generation plans, training, and resources supporting high-quality scientific exchange.
Synthesize insights from external experts, field teams, advisory boards, and other medical activities, and communicate their implications to internal stakeholders.
Serve as the PDAC medical content expert on US cross-functional teams and provide scientifically balanced medical input into strategic discussions and decisions.
Partner with HEOR/RWE, Clinical Development, and Biomarker/Companion Diagnostics teams on evidence-generation priorities addressing US clinical practice, patient identification, biomarker testing, treatment sequencing, safety management, and patient outcomes.
Coordinate gap assessments and contribute to publication, congress, medical communications, and evidence-generation plans aligned with the US medical strategy.
Support the development and review of scientific materials, medical education content, medical information response documents, abstracts, manuscripts, and data-disclosure materials.
Provide medical leadership for US congress planning, scientific symposia, advisory boards, and other medical activities, ensuring consistency, scientific accuracy, and compliance.
Partner with Patient Advocacy and Grants teams to incorporate patient and caregiver perspectives and help identify appropriate independent medical education priorities.
Collaborate with Safety and Clinical teams to support education and scientific exchange related to adverse-event recognition and management in PDAC.
Ensure all activities comply with applicable legal, regulatory, and compliance requirements.