Director, US Medical Affairs, NSCLC

Revolution Medicines

2d•$201,000 - $251,000•Remote

About The Position

The Director, US Medical Affairs – Non-Small Cell Lung Cancer (NSCLC) supports development of the US medical strategy and leads execution of assigned medical priorities across the NSCLC portfolio. The role spans first-line and subsequent-line treatment settings, including pre-launch planning, launch readiness, post-approval medical activities, and lifecycle planning. As a member of the US Medical Affairs Team, the Director translates evolving clinical evidence, external expert perspectives, and field insights into medical objectives and actionable plans. The individual serves as an NSCLC scientific expert and partners across US and Global Medical Affairs and multiple cross-functional teams. The role calls for strong lung cancer expertise, scientific rigor, hands-on Medical Affairs experience, clear communication of complex evidence, cross-functional influence, and the ability to manage multiple priorities in a fast-paced environment.

Requirements

Advanced clinical or scientific degree such as PharmD, PhD, MD, DO, or equivalent.
10+ years of relevant experience in biotechnology or pharmaceutical Medical Affairs and/or clinical oncology practice, including substantive hands-on Medical Affairs experience.
Strong scientific background in lung cancer, with direct NSCLC experience and an understanding of biomarker-driven treatment and the US treatment landscape.
Ability to analyze, synthesize, and communicate complex clinical evidence with scientific accuracy and appropriate balance.
Hands-on experience across core Medical Affairs activities, including medical planning, external expert engagement, field medical partnership, medical communications, evidence generation, congresses, advisory boards, and training.
Ability to collaborate and influence across functions, manage multiple projects and stakeholders, and deliver against agreed priorities.
Excellent written, verbal, and presentation skills, sound judgment, and commitment to ethical scientific exchange.
Ability to travel approximately 30–40% for external expert engagements, medical congresses, and internal meetings, including visits to Redwood City headquarters.

Nice To Haves

Established relationships with US thoracic oncology experts, investigators, and multidisciplinary care stakeholders in academic and community settings.
Experience supporting US oncology launch readiness, launch execution, or post-launch medical strategy.
Experience in precision oncology, RAS biology, targeted therapies, molecular testing, and companion diagnostics.
Experience supporting clinical-trial strategy or execution, including protocol review, site engagement, enrollment support, and clinical data interpretation.
Experience contributing to guideline or compendium submissions, such as NCCN, and collaborating with Global Medical Affairs on integrated medical and evidence-generation plans.

Responsibilities

Contribute to the US NSCLC medical strategy and annual portfolio plan, and lead assigned tactics with clear objectives, timelines, budgets, and measures of impact.
Conduct evidence and practice-gap assessments, incorporating US treatment patterns, stakeholder needs, competitive developments, and field insights to refine medical priorities.
Support launch readiness, launch execution, and lifecycle planning across NSCLC assets in alignment with US and Global Medical Affairs strategies.
Lead or support scientific engagement with US external experts through advisory boards, investigator interactions, congress activities, and peer-to-peer scientific exchange.
Partner with US Field Medical on scientific priorities, insight-generation plans, training, and resources that support high-quality scientific exchange.
Synthesize insights from external experts, field teams, advisory boards, and congresses; communicate implications and recommend actions to internal stakeholders.
Serve as an NSCLC medical content expert on cross-functional teams, providing scientifically balanced input into US strategic discussions and decisions.
Partner with HEOR/RWE, Clinical Development, and Biomarker/Companion Diagnostics teams on evidence-generation priorities, including patient identification, molecular testing, treatment sequencing, safety management, and patient outcomes.
Collaborate with Clinical Development, Clinical Operations, and Field Medical to support protocol review, site and investigator engagement, and appropriate trial awareness and enrollment activities.
Contribute to publication, congress, medical communications, and data-disclosure plans; develop or review scientific presentations, abstracts, manuscripts, educational content, and medical information response documents.
Provide medical leadership for assigned US congress activities, scientific symposia, advisory boards, and internal education, ensuring scientific accuracy and consistency.
Partner with Patient Advocacy to incorporate patient and caregiver perspectives, and with Grants teams to identify priorities for independent medical education.
Collaborate with Safety and Clinical teams on education and scientific exchange concerning adverse-event recognition and management in NSCLC.
Manage assigned vendors and resources, track execution and outcomes, and conduct all activities in accordance with applicable requirements, company policies, and Revolution Medicines Core Values.