Manufacturing Supervisor, NGS TE Production

Twist Bioscience•South San Francisco, CA

8d•$45 - $50

About The Position

The Manufacturing Supervisor, NGS TE Production, performs, trains, and oversees production staff on synthetic and molecular biology workflows in a highly automated, high-throughput manufacturing environment. The role manufactures and analyzes custom gene products across Twist Bioscience’s proprietary workflow, following SOPs and the daily production schedule. As the main contact for shift operators, the supervisor ensures the team follows the plan of record, sets priorities, provides guidance, leads troubleshooting, and manages information handoffs between shifts. The role also supports process improvement and documentation, maintains 5S systems, and works in a LEAN, controlled laboratory environment with knowledge of GLPs and familiarity with GMP or ISO-rated production. The specified schedule is Shift 2B: Wednesday–Friday with alternate Saturdays, 7:00 p.m.–7:30 a.m. The role may require work outside regular hours or a flexible shift as needed. The position is California-based; the San Francisco Bay Area base pay range is $45–$50 per hour. The role is also eligible for bonus, equity, and a benefits package.

Requirements

A.S. or B.S. in Biology, Chemistry, or Biochemistry.
At least 5 years of laboratory experience in a manufacturing environment.
Experience operating liquid handlers such as Hamilton and Tecan.
Experience with sample-tracking software and interfaces between robotic instrumentation and LIMS/MES systems.
Experience working in ISO, GMP, and LEAN manufacturing environments and applying lean manufacturing concepts.
Excellent scientific computation and data analysis skills.
Experience assessing current processes and techniques and implementing procedural improvements.
Experience leading small teams in a laboratory environment.
Strong problem-solving and communication skills.
Ability to stand for long periods while performing duties.
Ability to work safely with chemicals and hazardous materials.
Ability to lift up to 20 pounds.
Ability to work outside regular hours or a flexible shift as needed.
Knowledge of good laboratory practices (GLPs).
Comfort working in a LEAN manufacturing, controlled laboratory environment.

Nice To Haves

Experience with instrumentation for PCR, cell-based cloning, miniprep extraction, and purification.

Responsibilities

Manufacture high-quality custom gene products in a high-throughput manufacturing lab according to established SOPs.
Maintain thorough, accurate documentation of work in batch records, databases, and other approved formats, including problems and deviations.
Operate semi-automated and automated laboratory equipment for molecular biology workflows.
Track product-quality metrics using physical and functional test methods.
Apply scientific principles to troubleshoot and problem-solve test results.
Identify production problems and recommend solutions involving laboratory techniques, protocols, processes, and product or equipment handling.
Uphold standards defined by the manufacturing process.
Support continuous cost and process improvement initiatives.
Work safely at all times.
Maintain and calibrate select laboratory equipment.
Lead shift pass-down efforts and prioritize workflows.
Take accountability for the shift when senior personnel are not on site.
Advise on meeting schedules and technical problem resolution, and provide production guidance to junior manufacturing staff.
Schedule staff.
Review and verify production batch records and manufacturing documents.
Write and submit incident reports, CAPAs, planned deviations, and related documentation.
Follow regulatory and ISO 13485 requirements.
Perform, train, and oversee staff on molecular biology workflows.
Ensure the shift team works to the plan of record, set priorities, and lead troubleshooting.