Manager of Bioinformatics (Oncology Product Development)

Natera

12d • $140,000 - $175,000 • Remote

About The Position

Natera is seeking a Bioinformatics Manager to join the Bioinformatics team focused on Oncology Product Development. The role manages Bioinformaticians and Data Scientists and provides technical leadership in the design, development, and validation of ctDNA-based diagnostic tests. It involves extensive cross-functional collaboration with biostatistics, molecular biology, software engineering, and commercial departments. The ideal candidate has a strong background in bioinformatics and data science, preferably with experience in LDT assay development, and a record of project and technical leadership.

The position leads product development through validation and commercial launch, optimizes diagnostic workflows and analysis pipelines, and guides team members’ technical contributions and professional development. It also contributes to experiment design, interpretation, intellectual property, rigorous data analysis standards, and high-quality documentation.

Requirements

• Master’s degree or Ph.D. in a quantitative discipline such as bioinformatics, engineering, applied mathematics, or statistics.
• 4–8 years of post-graduate experience in data science and/or bioinformatics.
• 1–3 years of experience as a technical lead in diagnostics or a related field.
• Experience moving algorithm-based products through commercialization and launch in a medical or biological application, such as diagnostic testing, medical imaging, or biotechnology.
• 1–2 years of management experience leading a technical team, with demonstrable leadership and team-management skills.
• Experience using Python or R for scientific data analysis and visualization.
• Strong foundation in statistical modeling and machine learning, including probability theory and estimation/classification methods.
• Experience analyzing next-generation sequencing data, preferably including algorithm development or optimization.
• Ability to apply mathematical principles to solve real estimation problems and implement practical solutions.
• Excellent analytical, problem-solving, and decision-making skills, including the ability to work independently and find creative solutions to moderately complex problems.
• Experience leading technical projects, including defining and meeting milestones, delegating tasks to junior team members, and ensuring the quality of technical deliverables.
• Excellent communication skills and willingness to work in a dynamic, collaborative environment.

Nice To Haves

• Prior experience analyzing cancer-associated variant detection data.
• Experience in the LDT assay development space.

Responsibilities

• Provide technical leadership for product development projects, represent the bioinformatics team in cross-functional interactions, and move products through development, validation, and commercial launch.
• Lead efforts to optimize workflows, improve tools, and pressure test diagnostic analysis pipelines, including cancer-associated variant detection and evidence-based quality-control thresholds.
• Supervise bioinformatics scientists and data scientists, manage their technical contributions, prioritize resources, and support their technical and professional development.
• Provide input on experiment design, analysis, and interpretation using expert knowledge of Natera’s technology and relevant mathematical principles.
• Carry out assignments with a high degree of independence and responsibility.
• Contribute to the company’s intellectual property portfolio.
• Set standards for rigorous data analysis and lead the production of high-quality documentation.

Benefits

• Comprehensive medical, dental, vision, life, and disability plans for eligible employees and their dependents.
• Free testing for employees and their immediate families.
• Fertility care benefits.
• Pregnancy and baby bonding leave.
• 401(k) benefits.
• Commuter benefits.
• Employee referral program.

What This Job Offers

• Job Type: Full-time
• Career Level: Manager