Manager of Bioinformatics (Oncology Product Development)

Natera•San Carlos, CA

11d•$154,000 - $192,500

About The Position

Natera is seeking a Bioinformatics Manager to join its Bioinformatics team focused on Oncology Product Development. The role manages a team of Bioinformaticians and Data Scientists and provides technical leadership in the design, development, and validation of ctDNA-based diagnostic tests. It requires extensive cross-functional collaboration with biostatistics, molecular biology, software engineering, and commercial departments. The ideal candidate has a strong background in bioinformatics and data science, preferably with experience in laboratory-developed test (LDT) assay development, and a record of project and technical leadership. The manager leads product development from early development through validation and commercial launch, improves diagnostic analysis workflows and pipelines, and supervises team members’ technical contributions and professional development. The role also contributes to intellectual property and establishes standards for rigorous analysis and high-quality documentation. The position is eligible for additional compensation and benefits through Natera’s Total Rewards program.

Requirements

Master’s degree or Ph.D. in a quantitative discipline such as bioinformatics, engineering, applied mathematics, statistics, or a similar field.
4–8 years of post-graduate experience in a data science and/or bioinformatics role.
1–3 years of experience as a technical lead in diagnostics or a related field.
Experience moving algorithm-based products through commercialization and launch in a medical or biological application, such as diagnostic testing, medical imaging, or biotechnology.
1–2 years of management experience leading a technical team, with demonstrable leadership and team-management skills.
Experience using Python or R for scientific data analysis and visualization.
Strong foundation in statistical modeling and machine learning, including probability theory and estimation/classification methods.
Experience analyzing next-generation sequencing data, preferably including algorithm development or optimization.
Ability to apply mathematical principles to solve real estimation problems and implement practical solutions.
Excellent analytical, problem-solving, and decision-making skills, including the ability to make sound judgments independently and find creative solutions to moderately complex problems.
Experience leading technical projects, including defining and meeting milestones, delegating tasks to more junior team members, and ensuring the quality of technical deliverables.
Excellent communication skills and willingness to work in a dynamic, collaborative environment.

Nice To Haves

Prior experience analyzing cancer-associated variant detection data.
Experience in the LDT assay development space.

Responsibilities

Provide technical leadership for product development projects, represent the bioinformatics team in cross-functional interactions, and move products through development, validation, and commercial launch.
Optimize workflows, improve tools, and pressure test diagnostic analysis pipelines, including cancer-associated variant detection and evidence-based quality-control thresholds.
Supervise bioinformatics scientists and data scientists, manage their technical contributions, prioritize resources, and support their technical and professional development.
Provide input on experiment design, analysis, and interpretation based on understanding of Natera’s technology and relevant mathematical principles.
Carry out assignments with a high level of independence and responsibility.
Contribute to Natera’s intellectual property portfolio.
Set standards for rigorous data analysis and lead the production of high-quality documentation.