Infectious Disease In Vivo Cancer Vaccine Scientist

AstraZeneca • Gaithersburg, MD

4d • $92,252 - $130,378 • Onsite

About The Position

AstraZeneca is seeking a highly motivated and broadly skilled bench scientist with in vivo technical and immunology expertise to join the Virology and Vaccine Discovery group in Gaithersburg, MD. This scientist will be a key member of a team focused on developing next-generation cancer vaccines through the drug discovery process. The position requires a strong interest in vivarium and laboratory bench work to drive projects forward. AstraZeneca has a dynamic environment that fosters collaboration and innovation, attracting and nurturing top talent.

Requirements

• B.S. in Virology, Molecular Biology, Microbiology, Immunology, Cell Biology, or related scientific discipline with 2+ years of experience or M.S. in Virology, Molecular Biology, Microbiology, Immunology, Cell Biology, or related scientific discipline
• Broad experience desired in oncology, immunology, and vaccinology
• Advanced knowledge of animal handling techniques, including intramuscular, intranasal, subcutaneous, and intravenous immunizations, and euthanasia
• Advanced knowledge of tumor harvesting and other tissue processing, i.e. lymph nodes and spleen
• Experience with mouse tumor model development is strongly desired
• Knowledge of flow cytometry sample acquisition and data analysis is strongly desired
• Experience with automation is desired
• Ability to multitask and prioritize among numerous projects
• Strong interpersonal and collaborative skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment
• Ability to work in a collaborative, fast-paced environment while planning and meeting timelines
• Proven track record of success in your research and experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters)
• Strong verbal and written communication skills
• Must be able to understand, conduct and interpret results of technically challenging experiments with supervision.
• Ability to work independently as well as part of team is expected.

Responsibilities

• Design, manage, and conduct in vivo rodent studies to support the development of cancer vaccines targeting host tumor antigens and endogenous retroviruses
• Perform immunizations, tumor implantations, and necropsies, collect and process tissues and blood products for downstream immunological assays
• Conduct in vitro immunological assays to support the development of vaccines, including flow cytometry, ELISpot, and ELISA
• Design, execute and interpret results from animal studies to characterize biologic therapies directed against tumor antigens as part of vaccine antigen discovery efforts
• Work collaboratively with colleagues across the organization (e.g. protein engineering, bioinformatics, pathology, and translational medicine) to drive projects towards successful completion

Benefits

• short-term incentive bonuses
• equity-based awards
• qualified retirement programs
• paid time off (i.e., vacation, holiday, and leaves)
• health, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level